Ph.D. Weizmann Institute 2004
M. Sc. Biochemistry, Tel-Aviv University 1998
B.Sc. Biology. Tel-Aviv University 1995
Our laboratory investigates how proteases and regulated proteolysis control cellular homeostasis and contribute to human disease. We focus on the molecular mechanisms that govern protease specificity, regulation, and integration into cellular signaling pathways.
A major area of interest is the role of mitochondrial and cytosolic proteases in stress responses and neurodegeneration, including the PARL protease and its involvement in Parkinson’s disease–related pathways. In parallel, we study how N-terminal protein modifications, such as Nt-acetylation, influence protein stability, recognition, and protease-mediated turnover. Our research also extends to conserved proteolytic systems in bacteria, including NblA-dependent pathways that regulate adaptive protein degradation.
Methodologically, our work combines biochemistry, cell and molecular biology, and advanced mass-spectrometry-based proteomics to map protease activity, substrates, and interaction networks in complex biological systems.
Cris Webpage: https://cris.technion.ac.il/en/persons/oded-kleifeld/
We are applying these tools to:
