“Epigenomics of DNA methylation and chromatin structure”
Abstract:
DNA methylation epigenetically regulates genetic elements across eukaryotes. Inside the nucleus the DNA is wrapped by histone proteins and additional factors into a condensed fiber known as chromatin. Besides packaging the DNA, the chromatin evolved to regulate the accessibility of the DNA. While the genome can be naturally subdivided into genes and transposable elements, my results suggest that all genomic sequences are part of a chromatin continuum that cuts across transposon and gene annotations and better explains how DNA methylation machineries reach their target sites.
מארחת: פרופ”ח פיליפה מלמד
Dr Assaf Zemach, Department of Plant & Microbial Biology, University of California, Berkeley.
