I am very happy to open this year’s Faculty Seminar Series at 1:00 p.m. on Monday, November 10, with a talk by Prof. Gil Ast of Tel Aviv University. Prof. Ast will present a talk titled “3D Genome Organization Directs Alternative Splicing.”
You’re invited to enjoy pizza at 12:30 p.m. on Monday, November 10, at the Biology Auditorium.
Talk Abstract:
Alternative splicing is a major contributor to the creation of human genomic complexity. However, this comes at a price: it also contributes dramatically to higher levels of genetic disorders and cancer. Understanding how alternative splicing drives human complexity is one of the major questions we address in my lab. We were the first to show that chromatin organization and epigenetic markers regulate alternative splicing. We demonstrated that they exert this regulation by modulating the elongation rate of RNA polymerase II. We further discovered that the genome contains two distinct gene architectures—one that primarily resides in the nuclear center and another in the nuclear periphery. Cancer-associated mutations in each of these architectures lead to different outcomes on alternative splicing. Overall, I will present how 3D genome organization directs alternative splicing.
Some details about his research and publications can be found at:
https://www.astlab.sites.tau.ac.il/
Looking forward to seeing you!
Maya
