Seminars

→

→

→

13 →

→

→

→

→

1 →

→

→

→

→

1 →

1 →

I am very happy to open this year’s Faculty Seminar Series at 1:00 p.m. on Monday, November 10, with a talk by Prof. Gil Ast of Tel Aviv University. Prof. Ast... →

“Game of Edits” - A-to-I RNA Editing: Thrones of Regulation, Gametogenesis and Embryogenesis   Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADARs, is a widespread and evolutionarily conserved modification needed to... →

  Immune Profiling in CD59 Deficiency: From Single-Patient scRNA-seq to Therapeutic Insights CD59 deficiency is a rare disorder in which cells are vulnerable to uncontrolled complement-mediated immune attacks. To investigate... →

Phage Resistance in Synechococcus sp. WH8109    Phage resistance plays a central role in shaping cyanobacterial population dynamics and their interactions with viruses in the ocean. The coexistence of resistant... →

Inside and Out: Antigen Type Shapes T-Cell Engager Performance Across Intracellular and Extracellular Targets   Bi-specific T-cell engagers (BiTEs) are engineered antibodies that redirect a patient’s own T cells to... →

Spatio-temporal microbial evolution dynamics  In natural microbial communities, antagonistic interactions among bacterial species, or between bacteria and phages, are important drivers of community evolution and ecological dynamics. These natural environments... →

Locally synthesized glycyl aminoacyl tRNA synthetase (GARS1) is important for  local translation in neurons Regulation of gene expression is essential for neuronal development and function. A prominent regulatory mechanism involves... →

Developing computational approaches for predicting nucleic acid binding proteins and their targets   Nucleic acid binding proteins, and specifically DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs), play a central role... →

The cumulative effect of cannabinoids on the immune system in IBD mouse models   Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract, and current... →

Investigating MMP12⁺ Macrophages as Potential Modulators of Islet Vulnerability in Type 1 Diabetes Type 1 diabetes is an autoimmune disease that leads to the selective destruction of insulin-producing pancreatic beta... →

  New players in mitochondrial protein import quality control13 Mitochondria import most of their proteins from the cytosol via dedicated channels in the outer membrane. This process is complex, and... →

13 The ubiquitin-proteasome system plays a crucial role in excessive muscle proteolysis during atrophy, a condition triggered by inactivity, starvation, aging, cancer, and muscular dystrophies. While ubiquitin ligases (E3s) have... →

 Title: Structure Prediction and Sequence Phylogeny of Fusion Family (FF) Proteins Indicate a Common Ancestor in Nematodes and Horizontal Gene Transfer Origin in Non-Nematodes13 The fusexin superfamily comprises proteins that... →

  A toolkit to decipher mechanistic insights of long non-coding RNAs based on guided CRISPR screens Long non-coding RNAs (lncRNAs) are a large and diverse group of non-protein-coding genes whose... →

Towards the Design of Targeted Therapeutics based on Microbial and Antimicrobial    Amyloids, long thought to be defined by their classic cross-β fibril structure, have recently revealed a surprising new... →

High-throughput mapping of transposon-driven genomic rearrangements under antibiotic stress   Transposons and insertion sequence (IS elements) facilitate bacterial adaptation to antibiotics through two main mechanisms. In regular transposition (insertion), an... →

Dear all,   On Tuesday, July 8th, we are delighted to host Prof. Ting Chen of Tsingua University for a special research seminar. Prof. Chen is a leading figure in computational... →

On Tuesday, July 8th, we are delighted to host Prof. Ting Chen of Tsingua University for a special research seminar. Prof. Chen is a leading figure in computational biology and medical... →

 Age-dependent differences in neuroblastoma microenvironment: integrative analysis of human and mouse single-cell RNA sequencing data   This research investigates the molecular basis of age-dependent outcome disparities in neuroblastoma, the most... →

Dear all,   Our next seminar will be given by Dr. Ayala Shiber from the Technion Faculty of Biology   Place and time: Biology auditorium, Monday 30/6 at 13:00.  ... →

Intermittent Fasting to Attenuate Age-Related Muscle Atrophy In Aging C57BL/6 Mice: Study of the Underlying Molecular Mechanisms   Sarcopenia, the age-related loss of muscle mass and strength, contributes to frailty,... →

    Split-ADAR System to Detect in vivo Co-translational Cooperativity in Single-Molecule Resolution   Protein biogenesis is challenging in the crowded cellular environment, where off-pathway interactions can lead to protein... →

Unveiling a new human SEF (IL-17RD) function in breast cancer prevention →

Dear all,   Our next seminar will be given by Dr. Ifat Sher from the Sheba Medical Center and Tel-Aviv University   Place and time: Biology auditorium, Monday 16/6 at 13:00.... →

Dear all,   Our next seminar will be given by Dr. Shay Stern from the Technion’s Faculty of Biology.   Place and time: Biology auditorium, Monday 9/6 at 13:00.  ... →

 Identification of false discoveries in sequencing data   Sequencing techniques are fundamental in almost all genetic research, either by sequencing the entire genome or transcriptome, by high-throughput sequencing, or by... →

Studying developmental patterns of social interactions in C. elegans and their effects on individuality Individuals within the same population dynamically change their social interactions across development. Understanding how these long-term... →

Dear all,   Our next seminar will be given by Prof. Amit Zeisel from the Technion’s Faculty of Biotechnology and Food Engineering   Place and time: Biology auditorium, Monday 26/5... →

Dear all,   Our next seminar will be given by Dr. Einat Segev from the Weizmann Institute of Science   Place and time: Biology auditorium, Monday 19/5 at 13:00.   Title:... →

C8orf33: A novel regulator of DNA double strand break repair choice Living organisms are continuously exposed to exogenous and endogenous DNA-damaging agents that form DNA lesions. One of the most... →

  Dear all,   Our next seminar will be given by Prof. Naama Barkai from the Weizmann Institute of Science   Place and time: Biology auditorium, Monday 12/5 at 13:00.... →

  Exploring How Antigen Type Shapes CAR T Cell Sensitivity and Function   CAR T cell therapy has revolutionized cancer treatment, yet challenges remain in targeting solid tumors. This research... →

Dear all,   Our next seminar will be given by Prof. Alexander Bershadsky from the Weizmann Institute of Science and The Mechanobiology Institute, National University of Singapore   Place and... →

Dear all,   Our next seminar will be given by Prof. Gali Prag from the School of Neurobiology, Biochemistry & Biophysics, Tel-Aviv University.   Place and time: Biology auditorium, Monday 28/4... →

Dear all,   We will have a special faculty seminar given by Dr. Saurav Mallik from the Department of Molecular Genetics, Weizmann Institute of Science.   Place and time: Biology... →

Title:  Multi-Omics Profiling of Endocannabinoid System Remodeling in Aging Alzheimer’s Disease Mice The endocannabinoid system (ECS) plays a crucial role in regulating brain homeostasis, inflammation, and aging. In this seminar,... →

   Modulating Virulent Amyloids Via Nucleic-Acid and Small Molecules Proteins and peptides can aggregate into amyloid fibrils, while their formation, structure and function are influenced by environmental and biological factors.... →

CBR: A Novel High-Light Expressed Protein and its Potential for Carotenoid Binding Chlorella ohadii, a green desert microalga, is notable for its ability to thrive under extreme high-light intensities, a... →

T Cell Dysfunction in Aging and Disease My research focuses on T cell immunity in two contexts of dysfunction: (1) Inborn errors of immunity, focusing on CARMIL2 deficiency, where we... →

"Identification and characterization of DNA damage response lncRNA by spatial-temporal analysis” Long non-coding RNAs (lncRNAs) are emerging as key regulators of cellular function, with their spatial and temporal expression playing... →

The effect of adrenarche on the reproductive axis Adrenarche is a developmental process almost unique to humans in which the adrenal glands produce high levels of dehydroepiandrosterone (DHEA) ~2-3 years... →

Exploring Light Acclimation in Microalgae Light availability drives biochemical and molecular adaptations in aquatic algae. We studied eukaryotic algae in the red-shifted-light Hula Lake via spectral incubations and transcriptomic profiling.... →

The roles and regulation of Mkrn3 in mouse hypothalamic neurons Makorin Ring Finger Protein 3 (MKRN3) functions as a "pubertal brake," and loss-of-function mutations in MKRN3 are the most common... →

AI-Driven Research and Trait Aware Representations of Medical Diagnostics   Abstract   This seminar is devoted to two separate projects:   As AI promises to accelerate scientific discovery, it remains... →

Heme toxicity in the aged spleen impairs T-cell immunity through iron deprivation   Mechanisms of T cell aging involve cell-intrinsic alterations and interactions with other immune and stromal cells. Here,... →

Identification and characterization of novel quality control factors acting in a co-translational manner   At the critical junction of translation and protein folding, the ribosome serves as a central hub,... →

Science Communication Workshop: How to present your research effectively     Second meeting:3/2/2025, Four volunteers will give their presentation and will receive feedback from the audience (focusing on the presentation... →

Join us for a seminar exploring the metabolomic diversity of psilocybin-producing fungi and their effects on immune-related disorders. This research combines standardized extraction and analytical methods with metabolomic analysis and... →

Our next seminar will be given by Dr. Avner Wallach from the Faculty of Biology, Technion - Israel Institute of Technology Place and time: Biology auditorium, Monday 27/1 at 13:00.... →

Dear all,   Our next seminar will be given by Dr. Daria Amiad Pavlov from the Perelman School of Medicine, University of Pennsylvania.   Place and time: Biology auditorium, Monday... →

Dear all,   On January 13th the faculty seminar will be given by Prof. Oliver Hobert from the Department of Biological Sciences, Columbia University.   Place and time: Biology auditorium,... →

Dear all,   Our next seminar will be given by Prof. Oliver Hobert from the Department of Biological Sciences, Columbia University.   Place and time: Biology auditorium, Monday 13/1/2025 at 13:00.... →

  TCR-like Antibodies for B Cell Malignancies. Can They Overcome Resistance to Antibody-Based CAR T Cells? Chimeric antigen receptor (CAR) T cells directed at the CD19 surface protein are an... →

Dear all,   Our next seminar will be given by Dr. Neta Gazit Shimoni from the Department of Neuroscience, University of California at Berkeley.   Place and time: Biology auditorium,... →

Dear all,   Our next seminar will be given by Dr. Dor Russ from the Department of Biology, University of North Carolina at Chapel Hill   Place and time: Biology... →

Dear all,   Our next seminar will be given by Dr. Sahar Melamed from the Department of Microbiology and Molecular Genetics, Faculty of Medicine, The Hebrew University of Jerusalem.  ... →

Hydroxyapatite Deposition for 3D Bioprinting of Vascular Bone   Abstract This study investigates hydroxyapatite deposition within a bio-ink composed of fibrin, collagen, thrombin, calcium, and phosphate for the 3D bioprinting... →

The understanding of pathological body wall muscle cell fusion mediated by ectopic expression of the fusogen - EFF-1 in Caenorhabditis elegans.   Abstract: In vertebrates, skeletal muscle develops through myoblast... →

Dear all,   Our next seminar will be given by Prof. Yoav Gothilf from the School of Biochemistry, Neurobiology & Biophysics, the Faculty of Life Sciences, Tel-Aviv University.   Place... →

  Berta Eliad (Lamm Lab): "ADBP-1 regulates ADR-2 nuclear localization to control editing substrate selection", Nucleic Acids Research.   Feras Machour (Ayoub Lab): "Harnessing DNA replication stress to target RBM10... →

Dear all,   Our next seminar will be given by Dr. Yaniv Elkouby from the Department of Developmental Biology and Cancer Research, Faculty of Medicine, The Hebrew University of Jerusalem.  ... →

Title: Uncovering Neuronal Plasticity Following Associative Memory in C. elegans Associative learning enables animals to link a conditioned stimulus, like an odor, with an unconditioned stimulus, such as reward or... →

Title: "Using various single-molecular assays to measure the passage of RNA polymerase along the DNA template in optical tweezers" Abstract: Transcription is the subsequent step in the gene expression process.... →

Dear all,   Our next seminar will be given by Prof. Yasmine Meroz from the School of Plant Science and Food Security and the Center for Physics and Chemistry of... →

Title: Mitochondria dynamic and its translocation during cellular stress conditions   Abstract Mitochondria dynamics, motility, and translocation to distinct cellular regions by cytoskeleton-based machinery are essential for adapting to eukaryote cells' physiological... →

We invite you to join us for an engaging informal symposium where we will present and explain this year's Nobel Prize-winning breakthroughs in the fields of Physics, Chemistry, and Medicine.... →

Untargeted screening for small-molecule enzyme inhibitors via high-throughput metabolomics OMICS-based screening offers a promising approach for untargeted drug discovery. Recently, mass-spectrometry metabolomics and proteomics was used for inferring drug mechanism... →

Abstract: Understanding the intricate mechanisms governing epidermal pattern formation, particularly within ectodermal appendages like hair follicles, is a key pursuit in developmental biology. Reciprocal interactions between mesenchymal and epithelial cells... →

In search of pancreatic beta cells with a regenerative potential Shiran Rachel Peretz   Depletion of β cell mass is a key characteristic of diabetes, impairing insulin production and glucose... →

Cell-cell fusion during C. elegans male tail morphogenesis Cell-cell fusion is an essential process in the development and formation of body structures. The nematode Caenorhabditis elegans serves as a good... →

The effect of cell-laden bioink preparation and 3D bioprinting process on cells and on tissue formation This study addresses challenges in cultivated meat (CM) research, driven by the increasing demand... →

Structure-function Relationships in fibril forming Antimicrobial peptide Amyloid-like fibrils formed by antimicrobial peptides (AMPs) and microbial toxins hold significant promise as novel antimicrobial therapeutics and targets for antivirulence strategies. This... →

Overcoming Metabolic T-Cell Suppression in Cancer Immunotherapy Using Metabolic Engineering Cancer immunotherapy has shown remarkable success in hematologic cancers but remains less effective against solid tumors due to metabolic suppression... →

Dear all,   Our next seminar will be given by Dr. Or Shahar from the MIGAL Galilee Research Institute, Tel-Hai Academic College.   Place and time: Biology auditorium, Monday 5/8 at 13:00.   Title: Cell-type-specific... →

Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma Background and Motivation: Lung cancer has the highest mortality rate among all types of cancer worldwide. Strikingly, the RNA-binding... →

Dear all,   This week we will have four short talks by recent winners of the “paper of the month” award. Joshua Hazan, Bester lab Integration of transcription regulation and... →

Dear all,   Our next seminar will be given by Prof. Ravid Straussman from the department of Molecular Cell Biology, Weizmann Institute.   Place and time: Biology auditorium, Monday 22/7 at... →

Rhodopsin-carotenoid complexes in marine microorganisms Microbial rhodopsins are retinal-bound, light-activated membranal proteins found in diverse aquatic microbes. In the ocean’s photic zone, >50% of microbes harbor a rhodopsin gene, potentially... →

Seasonality of infection: Dynamics of cyanophage abundances and infection of their hosts Marine cyanobacteria are photosynthetic bacteria that are estimated to be responsible for a quarter of the ocean net... →

Dear all,   Our next seminar will be given by Prof. Gal Markel, the Director of Davidoff Cancer Center, Co-founder & Chairman of Samueli Integrative Cancer Pioneering Institute & Deputy Director General, Rabin... →

Mixing up the colors of the seas: Phototrophy by antenna-containing rhodopsins in aquatic environments Rhodopsin-based phototrophy is one of the two known ways by which microorganisms harvest sunlight energy. More... →

Biond Biologics – From Discovery and Application of Innovative Science to Breakthrough Biological Drugs for Cancer Treatment Speaker: Dr. Tehila Ben Moshe, CEO, Co-Founder, and Chairperson of the company In... →

Novel fungal MAP kinase signalling in response to a host plant small-molecule signal in the Cochliobolus-maize interaction Our study aims to investigate the relationship between fungi and their plant hosts... →

    Our next seminar will be given by Dr. Mor Nitzan from the School of Computer Science and Engineering, The Hebrew University, Jerusalem.   Place and time: Biology auditorium, Monday 24/6 at 13:00.  ... →

Novel enhancers in transcriptional regulation of the gonadotropin genes The pituitary gland luteinizing hormone (LH) and follicle stimulating hormone (FSH) control gonadal development and function, their levels changing dramatically at... →