Seminars

  The mechanistic origin of p53 selectivity and functionalityOne of the master transcriptional regulation hubs of every human cell is the transcription factor (TF) p53 protein. p53 is activated in... →

 “CRISPRscreen to identify lncRNA genes critical for SARS-CoV-2 infection” Coronavirus disease(COVID-19) is caused by the infection of Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2). The viral entry into host cells is mediated... →

 Throughoutthe last number of years, the non-protein-coding portion of the human genomehas gone from being considered “junk DNA” to “hot spots” in the area of lifescience. Genome-wide transcriptome studies indicate... →

Learn about great options in the industry at the interface of biologyand computer science Martin Akerman is a Technion Alumni who completed his undergraduate and  PhD at the Faculty of Biology.... →

Time: Thursday June 28th 13:00Place: hybrid- in the Faculty Auditorium/ZOOMhttps://technion.zoom.us/j/97658538324The HLA Peptidome of Lung Cancer: Towards the Developmentof Personalized ImmunotherapyLung cancer is the leading cause of cancer-related death worldwide, mainly... →

Title: Spatial transcriptomics ofmammalian tissuesAbstract: Mammaliantissues are composed of repeating anatomical units that are polarized bymorphogens or directional blood flow. As a result, cells at different tissuecoordinates sub-specialize in distinct physiological functions,... →

Title: Thinking outsidethe mouse: ex-vivo dissections of host-microbiome cross-talksKey points: ·        We developed a novel 3D gut organ culture system, as a uniquetool for studying host-microbiome interactions.·        Enteric neuro-immune-microbiome cross-talks control regulatoryand effector T-cells... →

Title: Rethinking Mammalian Embryonic Development: An Integrated View of Epigenetics and Cell CommitmentAbstract:One of the mostremarkable processes in biology is the development of a single fertilized egginto a complete multi-cellular embryo... →

Title:Activity Homeostasis in Neural Circuits: From Basic Principles to MalfunctionsAbstract:Maintaining averageactivity level within a set-point range constitutes a fundamentalproperty of central neural circuits. Accumulated evidence suggests that firingrate distributions and their means represent... →

Title: The power of ONE:Immunology in the age of single cell genomicsAbstract:The immune system is a complex, dynamic and plastic networkcomposed of various interacting cell types that are constantly sensing andresponding... →

Title: Innate immunity infungi: Is regulated cell death involved?Host: Benjamin Horwitz →

Title: From the Egg to the Kidney… and BackAbstract:Whatconnects the union of gametes at fertilization, a fundamental processthat ensures the transmission of genetic material through the generations, tothe defense against pathogens... →

Time: Tuesday May 17, 2022, 13:00 PMPlace: Hybrid – The Faculty og Biology AuditoriumZOOM: https://technion.zoom.us/j/91251316715Functional Super Molecular Structures of Self-assembled ProteinsAntimicrobial peptides are secreted by the innate immune system of... →

Title: New insights intoperoxisomes - small organelles with exciting biology and a huge impact on humanhealth.Abstract: Peroxisomes arecentral metabolic organelles whose decreased function gives rise to severe peroxisomaldiseases. It is recently becoming... →

Title: Physiological mechanisms of brain-body interactions Host: Sagi Levy →

Title: Decoding uniquitin signalsAbstract:UbiquitinE3-ligases regulate most of the cellular pathways and consequently are tightlyregulated themselves. Several allosteric mechanisms for regulation of HECTE3-ligases that were identified and characterized in our lab... →

Title: Nano drug delivery Host: Sagi Levy →

Title: The regulatory role of free ISG15Interferons(IFNs) are a group of cytokinesinduced by viral infection. IFN production leads to a series of protein conformationalrearrangements and interactions as well as production... →

Title: Howtranscription factors recognize binding sites in large genomes: the role ofintrinsically disordered regions.  Abstract:Transcription factors (TFs) regulate geneexpression by binding DNA sequences recognized by their DNA-binding domains (DBDs).DBD-recognized motifs... →

Place: hybrid- inthe Faculty Auditorium/ZOOM:https://technion.zoom.us/j/93473479861The role of pregnancy in skin regenerationAbstract: The physiology of mammalian skin changesdramatically during pregnancy due to immunological, metabolic, and hormonalshifts. Estrogens are major regulators of... →

Title:  Tracking the development and assembly of single cellsAbstract:  While high-throughput methods provide a sweepingbirds-eye view of development, different insights can be gained by zooming into study how a single cell... →

Title: Cis-acting gene regulationby long noncoding RNAs.  Abstract:It is now clear that many intergenic regions in eukaryoticgenomes give rise to a range of processed and regulated transcripts that do notappear... →

The ‘Hunger Games’- Structural Studies of the MC4 Receptor Reveal Mechanism for SatietyHost: Sagi LevyAbstract: Obesity is aglobal epidemic causing increased morbidity and impaired quality of life. Themelanocortin receptor 4 (MC4R)... →

Systematicidentification of gene-altering programmed inversions across the bacterialdomain Programmedchromosomal inversions allow bacteria to generate intra-population genotypicand functional heterogeneity, a bet-hedging strategy important in changingenvironmental challenges, such as bacteriophages and antibiotic drugs.... →

Title: Anti-tumor antibodies in ovarian cancer patients. Host: Sagi Levy →

Underlying mechanisms of re-programingreproduction following early life adversityA high burden of inflammatory diseasewas correlated with later puberty onset and earlier menopause in a study ofmigrant women, possibly suggesting an adaptive... →

Early-life experiencere-organizes neuromodulatory regulation of developmental patterns of behaviorand individuality   Early-life experiences may promote robust and long-lastingbehavioral outputs within populations, but also patterns of behavioralresponses that are variable among individuals, even... →

Decipheringthe role of alanine as a novel metabolic regulator of T cell immunity Abstract:T lymphocytes survey our body for threats. Under homeostasis, thesecells rarely proliferate. Upon encountering their cognate antigen and... →

The seminar will be given Hybrid: In the Faculty of Biology Auditorium and in ZOOM:https://technion.zoom.us/j/98596900607?pwd=UXk4eWk5dmZPOUFuMEl2Q1dCZ2puUT09Meeting ID: 985 9690 0607Passcode: 845596.Research Topic:Selection for resistance in marine cyanobacteria against generalist and specialist phages →

Title: Studying RNA Binding Proteins at Subcellular Resolution to Uncover their Roles in Health and Dysregulation in Disease Zoom: https://technion.zoom.us/j/96006672617 Abstract: Regulation of gene expression is at the basis of cell function.... →

Tcell starvation and nutrient competition at the tumor micro environment is considered a major limiting factor in cancer immunotherapy. Metabolic suppression hampers T cell activation, differentiation, and effector functions, leading... →

Title: Hair Raising Tale: Nerve – Stem Cell Interactions Zoom: https://technion.zoom.us/j/95140358269 Abstract: Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle, and the sympathetic nerve, providing a model to... →

Title: Filamentous actin drives nuclear architectural changes to maintain genome stability ZOOM:  https://technion.zoom.us/j/91878900904 Abstract: Cell proliferation requires efficient and accurate DNA replication. The complexity of replication, however, renders genome copying susceptible to endogenous... →

Title: The importance of being in the membraneZoom Link: :  https://technion.zoom.us/j/95594834686Abstract: With in cell membranes are numerous proteins and protein complexes that are responsible for the execution of a multitude of functions essential... →

Title: The diverse cellular and molecular mechanisms driving neuronal and axonal degenerationZoom: https://technion.zoom.us/j/98391777547Abstract: Aberrations in protein folding, processing and degradation are common features of neurodegenerative diseases, resulting in their accumulation. Amyotrophic lateral... →

Title: Toxoplasma gondii - a master manipulator: From effectordiscovery to novel concepts in cell death.Abstract: Toxoplasma gondii translocates effector proteins into its host cell tosubvert various host pathways. T. gondii effector TgIST blocks thetranscription... →

Antigen-SpecificImmunomodulation in Multiple Sclerosis by IL-10 -TCell Receptor-Like Antibodies (TCRL) Fusion ProteinsMultiple sclerosis (MS) is anautoimmune disease of the central nervous system (CNS) leading to demyelinationand disability. MS treatments are... →

Title: “Unravelling the microscale mechanisms driving particle degradation in the ocean”Abstract: The sinking of organic particles to the ocean depths is the main driving force of thebiological pump, the process... →

Regulation of mitochondrial trafficking by Myosin XIX during cell migration. Myosin XIX (Myo19) is an actin-based molecular motor that is anchored to the outer mitochondria membrane (OMM) via its unique... →

 Studying AlternativePolyadenylation in Human Cells and Clinical Samples during Human Cytomegalovirus (HCMV)Infection  HCMV infection is the leadingcause for congenital abnormalities in the western world. We studiedtranscriptomic changes in human fibroblast and... →

Title: What can fishes teach us about the brain?Abstract: Fishes have diverged in evolution from the mammalian linage some 450million years ago and as a result fishes’ brain structure is... →

Title: Golgi Redox and Gut Health: the Elegant Mechanism for ConstructingIntestinal MucusGuest: Deborah Fass, Departmentof Chemical and Structural Biology, WeizmannInstitute of Science AbstractThreats to the body’s physical integrity come in a... →

Title: Factors andmechanisms in mRNA localization and translationAbstract:The expression ofgenes into a functional unit is regulated at multiple steps, from the initial RNAtranscription, through its processing, intracellular localization, and finally... →

TitleSame organ, different place - conserved regulation of a transient stem-cellstate in the initiation of multiple root types AbstractPlantsadjust their post-embryonic growth in response to environmental cues by formingnew organs in... →

Title: Themulti-scale structure of chromatin in the nucleus Host: Sagi Levy →

The multi-scale structure of chromatin in the nucleusYuval GariniBiomedical Engineering Faculty,TechnionYuval.garini@technion.ac.il  ,  www.garini-lab.com/  The DNA in a human cell which is ~3 meters long is packed in a ~10 μmradius... →

“Computational approach to identifynew roles for long non-coding RNAs involved in pluripotency anddifferentiation” ecently long non coding RNAs (lncRNAs) have emerged asregulators of pluripotency and differentiation, however their contribution tospecific... →

“Computational approach to identify new roles for long non-coding RNAs involved in pluripotency and differentiation”Recently long non coding RNAs (lncRNAs) have emerged as regulators of pluripotency and differentiation, however their... →

DNA dynamicsdictates p53 functional outcomeTali E. Haran AbstractThe tumor suppressor protein p53 issituated in the midst of a complex cellular network that is activated inresponse to cellular stress. Activated p53 functions... →

DNA dynamicsdictates p53 functional outcomeTali E. Haran AbstractThe tumor suppressor protein p53 issituated in the midst of a complex cellular network that is activated inresponse to cellular stress. Activated p53 functions... →

Abstract:RNA editing is a highly conserved mechanism by which theAdenosine Deaminases Acting on RNA (ADAR) enzymes convert adenosines (A) intoinosines (I), which are recognized by the splicing and translationalmachineries as... →

Abstract:RNA editing is a highly conserved mechanism by which theAdenosine Deaminases Acting on RNA (ADAR) enzymes convert adenosines (A) intoinosines (I), which are recognized by the splicing and translationalmachineries as... →

A Computational Pipeline for the Quantification of Social Interactions Across DevelopmentLittle is known about how social behavior changes across different stages of development in animals. The nematode C. elegans offers... →

A Computational Pipeline for the Quantification of Social Interactions Across DevelopmentLittle is known about how social behavior changes across different stages of development in animals. The nematode C. elegans offers... →

Whilemobile genetic elements play a consequential part in bacterial adaptation andantibiotic resistance, relatively little is known about their role inwithin-host pathogen evolution. To explore their function, we constructed acomputational pipeline... →

Researchtopic: The dualrole of a cyanophage thioredoxinAbstract:Marinecyanobacteria are highly abundant photosynthetic organisms that contributegreatly to global primary production. Their viruses, marine cyanophages, arealso extremely abundant and have a major effect... →

Anchoredcells of the basal epidermis constantly undergo proliferation in an overcrowdedenvironment. One important regulator of epidermal proliferation is YAP, whichcan be controlled by both cell-matrix and cell-cell interactions. During myPh.D.,... →

Stem Cells: a Matter of Life and DeathStemcells ( play a pivotal role in fueling homeostasis and regeneration Whilemuch focus has been given to self renewal and differentiation pathways regulatingSC... →

 The development and growth of the plant body are regulated by aninterplay between plant hormone signaling pathways that both interpret anddetermine their accumulation and distribution. Brassinosteroids (BRs) are oneof these... →

Title: Improving T cell effector functionsby limiting mitochondrial-derived ATP transfer to the cytosolHost: Noga Ron Harel & Ayala Shiber Zoom: https://technion.zoom.us/j/93293373229 →

Title: "A novel microfluidic assay foradhesion-free migration reveals a polarized motility mode"Abstract:Cell motility is a key factor in various processes such ascancer metastasis, immune response, and wound healing.  The mode ofcell... →

Title: “Understanding the systemic control of proteostasis”Host: Ayala ShiberZoom: https://technion.zoom.us/j/93293373229 →

The regulation of Tet1 by steroidhormones in proliferating gonadotrope precursor cellsThe hydroxymethylase, Tet1, plays amajor role in regulating gene expression, and its knockdown specificallyaffects fertility. Reproductive function is activated by... →

Title: Unicellularand multicellular stress responses in bacterial biofilmsHost: Roy Kisony & Ayala ShiberZoom: https://technion.zoom.us/j/93293373229 →

Community-associated methicillin-resistant Staphylococcusaureus (CA-MRSA) has spread worldwide and is threatening public health. Itshallmark is the mecA gene, whichconfers resistance to nearly all β-lactam antibiotics. However, it is unknownwhether mecA provides... →

Seminarin memory of Prof. Dan Tawfik -“thedynamics and molecular mechanisms of microbial evolution”Host:  Ayala ShiberZoom https://technion.zoom.us/j/93293373229 →

Title: “Structural and energy-based modeling of protein complexes: biotechnological applications ”Host: FabianGlasser& Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229     →

Title:Invivo Multi Scale Imaging of Vascular-Immune Interactions in CardiovascularDisease”Host: Dvir Aran & Ayala ShiberZoom: https://technion.zoom.us/j/93293373229 →

, " Evolutionary paths tohigh-level ampicillin resistance ""  Thewidespread use of beta-lactams has resulted in a growing prevalence of highlyresistant pathogens.Indeed, clinical isolates can have very high resistance to beta-lactams, mostprominently... →

Title: Theevolution of a complex morphology at a single-cell resolution”Host: Ayala ShiberZoom: https://technion.zoom.us/j/93293373229 →

Title: “KeepingTime with TranscriptionHost: Ayala ShiberZoom: https://technion.zoom.us/j/93293373229 →

Mechanisms of chemoresistance in relapsed AMLpatients: towards efficacious precision medicineAcutemyeloid leukemia (AML) remains a devastating disease with a 5-year survivalrate of less than 30%. AML treatment has undergone significant advances... →

Research Topic: Mass spectrometry approaches for studying cancermetabolism  Mass spectrometry based metabolomics is a widely usedapproach in biomedical research. However, current methods coupling massspectrometry with chromatography (LC-MS) are time-consuming and... →

Title: Weight loss dependentand independent effects of weight-loss surgery    Host: Sagi Levy & Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229     →

Title:“Implementing logic gates in cancer immunotherapy    ”Host: OfirLevin-Piaeda& Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229     →

Title:  "The Cys Sensing: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins" Host: Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229     →

Title:“Researchin the data-rich biomedical era to advance precision medicine”Host: Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229     →

An ordered loss ofdesminfilaments precedesand promotes muscle atrophyMyofibril breakdown is a hallmarkof muscle wasting and an inevitable sequel of aging and disease. The desmincytoskeleton is critical for skeletal muscle architecture... →

BiophysicalProperties that Influence Optimal Functional Output of TCR Engineered T Cells Theencounter of the TCR with its cognate peptide-MHC complex (pMHC) is a crucialstep in T-cell activation. One of the most... →

Insulinreceptor turnover in fasting is dependent on b-dystroglycan deglycosylationFasting exertsvarious physiological effects, most notably, reduced signaling through theinsulin receptor. Insulin receptor activity requires association withDystrophin Glycoprotein Complex (DGC), and fasting... →

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took... →

Title:Structure-function analysis of EFF-1 mediated cell-cell fusion Cell-cellfusion is a universal multi-step process essential for organogenesis and sexualreproduction. EFF-1 protein and its paralog AFF-1 are necessary and sufficientfor fusion in the... →

Title: “The HLA peptidome – its cellular production pipeline andclinical usefulness”Host: Ayala Shiberhttps://technion.zoom.us/j/96789984896 →

Characterizing the auxiliarynucleotide binding sites in RecBCDDNA helicase, towards deciphering their functional roleAbstract:RecBCD is aDNA helicase-nuclease, powering the initiation of dsDNA break repair. It is ahighly processive fast helicase, with... →

Title: TBAHost: Ayala Shiberhttps://technion.zoom.us/j/91816487260     →

TitleA single molecule study of protein-DNAinteractionsAbstract Bindingof transcription factors (TFs) to regulatory regions in the genome is crucialfor the initiation of transcription, and thus one of the most important layersin... →

Title: “Lost in Translation: the Ribosomal Epitranscriptome in Hematopoiesis” Host: Ayala Shiber ZOOM →

Title: Investigatingthe cell biology of plant infection by the rice blast fungus MagnaportheoryzaeHost: Ayala Shiber →

Title: Studying the interplay between autophagy andmetabolism in plants Host: Ayala ShiberZoom: https://technion.zoom.us/j/97980014119 →

“A meristematic state depends on atissue specific-incoherent effect of steroid hormones”The entire plant body can be traced backto the activity meristems, tiny organized structures   harboring the stem cells niche. Thisactivity... →

Title: 4EBP is exploited by tumor cells to adapt toglucose starvationHost: Ayala ShiberZoom: https://technion.zoom.us/j/99516266251 →

Breastcanceris not a single disease, it is comprised of many biologically differentfeatures with distinct pathological and clinicalimplications. Accumulating evidence suggest breast cancers with different histopathological andbiological features exhibit different behaviors... →

Identification of a novel pathway to ensure double strand break-inducedtranscriptional silencing and repairDouble-strand break (DSB) are the most cytotoxic form DNA damageand defective DSB repair leads to genomic instabilities that... →

Title: The endocannabinoid system and its therapeutic potentialHost: Ayala ShiberZoom: https://technion.zoom.us/j/93644157337 →

DanielZaidmanFrom the Lab ofDr. Nir London  Weizmann Institute of Science  Computational protocols for thedesign of next generation chemical tools.Covalent irreversible inhibitors, andprotein degraders (PROTACs) are two emerging fields that are growing... →

Title: Toward HCV vaccine - Structural studies of HCV E2 envelopglycoprotein that facilitates rational design of HCV vaccine. Host: Ayala Shiber →

A single molecule study of theroles of the RecC subunit in DNA unwinding by RecBCD DNAdouble-strand breaks (DSBs) are the most cytotoxic of DNA lesions and theirrepair requires a comprehensive and... →

Title: Softmembranes & rigid filaments: a role for endoplasmic reticulum in thecellular distribution of microtubules Host: Ayala Shiber →

Title: Neuronal regulation of proteostasis collapse inCaenorhabditis elegans Host:Ayala Shiber →

Title: Molecular Chaperones in Protein Disaggregation - What wecan learn by NMR Host:Michael Glickman and Ayala Shiber →