Seminars

Studying RNA transcription regulation via RNA-binding proteins   DRBP are proteins capable of binding DNA and RNA. Due to their dual capacity, those proteins can act at different steps of... →

Transcription Factors-RNA interaction: a new layer of cellular regulation Gene expression is a complex process tightly regulated by various proteins, including DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs). However, little... →

The ins and outs of meristem function and shape   Abstract:   Growth extent and direction determine cell and whole-organ architecture. How they are spatio-temporally coordinated across distinct cell types... →

A dual role of RBM42 in modulating splicing and translation during DNA damage response: A spotlight on CDKN1A/p21 gene   Abstract p53-mediated cell cycle arrest during DNA damage is dependent... →

Precise patterning in the inner ear   Abstract:   Precise periodic organization of cells is required for the function of many organs and tissues. It is often unclear, however, how... →

Estrogen Receptor Modulation by a Newly-Identified Phytocannabinoid in a Preclinical Model of Breast Cancer Breast cancer is made up of different subtypes that respond differently to treatments. Tumors that express... →

Characterization of Peroxismoal Proteins Changes in Response to Stress   Peroxisomes are organelles with a single bilayer membrane that encloses a soluble matrix space. Their importance is highlighted by the... →

Anti-cancer compounds from East Mediterranean seaweeds This project is aimed to study the anti-cancer effect of the East Mediterranean seaweeds to point out seaweeds of interest for future investigation and... →

  ISG15 and ISGylation at the ribosome: mechanistic analysis, innate immune response, and impact on translation   The innate immune response is the first line of defense against all pathogens.... →

Developing a single molecule approach to selective ribosome profiling   mRNA-protein interactions are at the center of the translation process. Ribosome-associated factors, from modifying enzymes to molecular chaperones, play a... →

Understanding the turnover of the truncated form of mutant ubiquitin UBB+1, UBBG76Y Ubiquitin is a 76 amino acid molecule that labels proteins for degradation. Its C-terminus at 76 glycine is... →

Reference-based deep examination of single-cell RNA-seq clusters Identifying the biological state of each single cell is arguably the most challenging task in scRNA-seq data analysis. Doing so requires bridging the... →

Title: comprehensive terminomic characterization of biological systems. Seminar abstract: Protein termini carry valuable information related to protein activity, localization, interaction and stability. Learning these various properties can be detrimental to... →

  Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression   During solid tumor progression, the tumor microenvironment (TME) evolves into a highly immunosuppressive... →

An Internal Model of Sensorimotor Context in Freely Swimming Electric Fish Internal models that predict the sensory consequences of motor actions are vital for sensory, motor, and cognitive functions. However,... →

Immunomodulation of EAE with Antibodies Targeting Autoreactive T-Cell Epitopes   Multiple sclerosis (MS) is a demyelinating autoimmune disease influencing more than 2.5 million people around the world. Damage caused in... →

The UPRmt coordinates mitochondrial network expansion and peroxisome biogenesis in the model organism Caenorhabditis elegans As organisms develop, individual cells generate mitochondria and peroxisomes to fulfill their physiological requirements. A... →

Oligodendrocyte plasticity in cognitive aging and neurodegeneration Abstract Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain aging.... →

Posters that were chosen as excellent in the departmental research days, will be presented by the graduate students. A panel of judges will choose the winning posters. A “Crowd Favorite”... →

Understanding the ancient evolution and function of innate immunity The human innate immune system has long been considered the result of extensive evolutionary innovations in metazoans. However, this dogma has... →

Study of Antigen Presentation and Antigen-Specific Immunomodulation in Multiple Sclerosis by T cell Receptor-mimic Antibodies During autoimmune diseases, like Multiple Sclerosis (MS), the immune system is downregulated in a non-specific... →

How One Eukaryotic Cell Invades Another: Dissecting Invasion by Apicomplexa The phylum Apicomplexa includes several of the most prevalent and important human eukaryotic pathogens, such as Plasmodium spp., which causes... →

Estrous cycle and Egg release resets inspired by neurodynamics in the circadian pacemaker   Jet lag and shift work disrupt the menstrual cycle and decrease fertility. The circadian pacemaker, the... →

The third lecture in the "Science Talk on the Bar" series of the Faculty of Biology About: • Is cannabis the antibiotics of the 21st century? • How many patients... →

Archaeal origins of gamete fusion Sexual reproduction consists of genome reduction by meiosis and subsequent gamete fusion. Fusexins, are a superfamily of structurally conserved proteins (fusogens) that mediate three types... →

Abstract: The fact that some amino acid chains fold alone into natively structured and fully functional proteins in solution, has led to the commonly accepted “one sequence-one structure” notion. However,... →

Arie Admon@70 symposia – Celebrating Arie's 35 years of Science "My Life with Mass Spectrometers, Proteomics, and Immunopeptidomics” Thursday, December 22, 2022; 10:00-15:00 Faculty of Biology Auditorium, Technion-Israel Institute of... →

Abstract: What are "Light Sensing" proteins and how were they discovered in the waters of the Sea of Galilee, for the first time since 1971? What is "harvesting solar energy",... →

Tales from the crypt: on helminth regulation of the stem cell compartment Abstract: Intestinal helminths remain pervasive throughout the animal kingdom by manipulating host defense pathways to prioritize tissue adaptation... →

Abstract All cells have evolved the means to store energy and thereby minimize the effects of fluctuations in nutrient availability. Cells store energy in the form of neutral lipids, such... →

During December, the faculty will hold a series of "Science TALKS over the counter" led by faculty PI in selected locations throughout Haifa and the north district. We are thrilled... →

  Reducing scRNA-seq data via nonnegative matrix factorization for annotation and clustering analysis abstract: Single-cell RNA sequencing (scRNA-seq) provides an unprecedented opportunity to dissect tissue heterogeneity and characterize individual cells.... →

Abstract Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain aging. Cerebrospinal fluid (CSF) makes up the immediate... →

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  https://en.globes.co.il/en/article-genome-sequencing-co-ultima-genomics-raises-600m-1001414037   Genome sequencing company Ultima Genomics has come out of stealth and announced $600 million in financing. Founded in 2016 by its Israeli CEO Gilad Almogy, the company... →

Tales of protein tails and the proteases that generate them Proteolysis is one of the mechanisms that allows cells to alter their proteome in response to different conditions or signals.... →

  Thermodynamic models for the homeostasis and development of the epidermis and spherical organoids Epithelial tissues formed of layered cell surfaces are prevalent in multiple tissues and play an essential... →

Abstract: Cellular plasticity is emerging as an important driving force underlying cancer progression and drug resistance. In this talk, I will discuss the concept of cancer cell states present in... →

Abstract:   The formal scientific method tells you how to rigorously and objectively test a hypothesis. But where do hypotheses come from in the first place? Posing fruitful new questions,... →

The Ayoub lab studies DNA damage repair, genome stability and cancer. Ayoub lab: http://ayoubn.net.technion.ac.il/ →

Graph Theory Approaches for Network Analysis of Neuronal Signals and Behavior How does the brain encode behavior? What are the internal mechanisms affecting neuronal network organization and configuration at different... →

Adult stem cells (SCs) are tissue-specific resident cells that serve to replenish and maintain the tissue. Two significant SC populations co-exist in the hair follicle: hair follicle SCs (HFSCs) and... →

Exocytosis by membrane crumpling maintains homeostasis during exocrine secretion Dynamic membrane remodeling is essential for life. Cells, organelles, and vesicles must constantly acquire, maintain and modify their shape and composition... →

10:00-10:30 - Gathering, coffee, and cakes 10:30-10:40 - Opening Remarks, Faculty Dean Yael Mandel Gutfreund 10:40-10:50 – Introduction, Yoram Reiter 10:50-11:20 - Michael Boshart, Genetics - Biocenter LMU, München Protein... →

"The Antitumor Effects of Cannabinoids in Glioblastoma Multiforme" Glioblastoma multiforme is an aggressive brain tumor whose current treatments are insufficient due to its high invasiveness and heterogeneity, rapid growth and... →

What mechanism protects the heart from fasting-induced atrophy? Skeletal muscles atrophy upon systemic fasting, when blood glucose and insulin levels are low. However, the heart is relatively protected, and atrophy... →

Revealing Hormone-Mediated Tissue-Specific Nuclear Proteome and Signaling Output in the Meristem Our lab seeks to understand the principles underlying developmental programs in plants. Using roots as a model organ, we... →

The Effect of Cannabinoids on Microglial Phagocytosis of Amyloid-beta: Implications for Alzheimer’s Disease During the progression of the neurodegenerative Alzheimer’s disease, amyloid-β peptides accumulate in the brain to form toxic... →

Title: Linking learning to behaviour via neural representation geometry. Abstract: Recent developments in experimental neuroscience enable us to simultaneously record the activity of a large number of neurons and to... →

Programmed Cell Death RegulatesSebaceous Gland Homeostasis and Pathology   In the past decade, most studies investigating mammalian skin havefocused on the epidermis and the hair follicle, whereas much less is... →

Apoptoticcells represent a dynamic stem cell niche governing proliferation and tissueregeneration   Summery Stem cells (SCs) play a key role inhomeostasis and repair. While many studies have focused on SC... →

Roles of Aminoacyl tRNA synthetases in mRNA regulation Aminoacyl tRNA synthetases (aaRSs) are a well-studied family of enzymes with a canonical role in charging tRNA with specific amino acid. Yet,... →

Studying the functionalsignificance of RNA editing and duplicated genomic regions in Caenorhabditiselegans RNAediting is a phenomenon of RNA sequence alteration after transcription ineukaryotes. In mammals, the most common alterations studied... →

Shape readout by the transcription factor ETS1 of its RE's   Transcription in eukaryotes is under the control oftranscription factors (TFs) binding to specific DNA binding sites. ETS proteinsare a... →

Research subject: The role of caspase-9 in hairfollicle stem cells. Summary: Programed cell death(PCD) serves many important functions in mammalian development and tissuehomeostasis. These include shaping tissue morphology during organogenesis... →

  One of the master transcriptional regulation hubs of every human cell is the transcription factor (TF) p53 protein. p53 is activated in response to cellular stress, and is involved... →

  The mechanistic origin of p53 selectivity and functionalityOne of the master transcriptional regulation hubs of every human cell is the transcription factor (TF) p53 protein. p53 is activated in... →

 “CRISPRscreen to identify lncRNA genes critical for SARS-CoV-2 infection” Coronavirus disease(COVID-19) is caused by the infection of Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2). The viral entry into host cells is mediated... →

 Throughoutthe last number of years, the non-protein-coding portion of the human genomehas gone from being considered “junk DNA” to “hot spots” in the area of lifescience. Genome-wide transcriptome studies indicate... →

Learn about great options in the industry at the interface of biologyand computer science Martin Akerman is a Technion Alumni who completed his undergraduate and  PhD at the Faculty of Biology.... →

Time: Thursday June 28th 13:00Place: hybrid- in the Faculty Auditorium/ZOOMhttps://technion.zoom.us/j/97658538324The HLA Peptidome of Lung Cancer: Towards the Developmentof Personalized ImmunotherapyLung cancer is the leading cause of cancer-related death worldwide, mainly... →

Title: Spatial transcriptomics ofmammalian tissuesAbstract: Mammaliantissues are composed of repeating anatomical units that are polarized bymorphogens or directional blood flow. As a result, cells at different tissuecoordinates sub-specialize in distinct physiological functions,... →

Title: Thinking outsidethe mouse: ex-vivo dissections of host-microbiome cross-talksKey points: ·        We developed a novel 3D gut organ culture system, as a uniquetool for studying host-microbiome interactions.·        Enteric neuro-immune-microbiome cross-talks control regulatoryand effector T-cells... →

Title: Rethinking Mammalian Embryonic Development: An Integrated View of Epigenetics and Cell CommitmentAbstract:One of the mostremarkable processes in biology is the development of a single fertilized egginto a complete multi-cellular embryo... →

Title:Activity Homeostasis in Neural Circuits: From Basic Principles to MalfunctionsAbstract:Maintaining averageactivity level within a set-point range constitutes a fundamentalproperty of central neural circuits. Accumulated evidence suggests that firingrate distributions and their means represent... →

Title: The power of ONE:Immunology in the age of single cell genomicsAbstract:The immune system is a complex, dynamic and plastic networkcomposed of various interacting cell types that are constantly sensing andresponding... →

Title: Innate immunity infungi: Is regulated cell death involved?Host: Benjamin Horwitz →

Title: From the Egg to the Kidney… and BackAbstract:Whatconnects the union of gametes at fertilization, a fundamental processthat ensures the transmission of genetic material through the generations, tothe defense against pathogens... →

Time: Tuesday May 17, 2022, 13:00 PMPlace: Hybrid – The Faculty og Biology AuditoriumZOOM: https://technion.zoom.us/j/91251316715Functional Super Molecular Structures of Self-assembled ProteinsAntimicrobial peptides are secreted by the innate immune system of... →

Title: New insights intoperoxisomes - small organelles with exciting biology and a huge impact on humanhealth.Abstract: Peroxisomes arecentral metabolic organelles whose decreased function gives rise to severe peroxisomaldiseases. It is recently becoming... →

Title: Physiological mechanisms of brain-body interactions Host: Sagi Levy →

Title: Decoding uniquitin signalsAbstract:UbiquitinE3-ligases regulate most of the cellular pathways and consequently are tightlyregulated themselves. Several allosteric mechanisms for regulation of HECTE3-ligases that were identified and characterized in our lab... →

Title: Nano drug delivery Host: Sagi Levy →

Title: The regulatory role of free ISG15Interferons(IFNs) are a group of cytokinesinduced by viral infection. IFN production leads to a series of protein conformationalrearrangements and interactions as well as production... →

Title: Howtranscription factors recognize binding sites in large genomes: the role ofintrinsically disordered regions.  Abstract:Transcription factors (TFs) regulate geneexpression by binding DNA sequences recognized by their DNA-binding domains (DBDs).DBD-recognized motifs... →

Place: hybrid- inthe Faculty Auditorium/ZOOM:https://technion.zoom.us/j/93473479861The role of pregnancy in skin regenerationAbstract: The physiology of mammalian skin changesdramatically during pregnancy due to immunological, metabolic, and hormonalshifts. Estrogens are major regulators of... →

Title:  Tracking the development and assembly of single cellsAbstract:  While high-throughput methods provide a sweepingbirds-eye view of development, different insights can be gained by zooming into study how a single cell... →

Title: Cis-acting gene regulationby long noncoding RNAs.  Abstract:It is now clear that many intergenic regions in eukaryoticgenomes give rise to a range of processed and regulated transcripts that do notappear... →

The ‘Hunger Games’- Structural Studies of the MC4 Receptor Reveal Mechanism for SatietyHost: Sagi LevyAbstract: Obesity is aglobal epidemic causing increased morbidity and impaired quality of life. Themelanocortin receptor 4 (MC4R)... →

Systematicidentification of gene-altering programmed inversions across the bacterialdomain Programmedchromosomal inversions allow bacteria to generate intra-population genotypicand functional heterogeneity, a bet-hedging strategy important in changingenvironmental challenges, such as bacteriophages and antibiotic drugs.... →

Title: Anti-tumor antibodies in ovarian cancer patients. Host: Sagi Levy →

Underlying mechanisms of re-programingreproduction following early life adversityA high burden of inflammatory diseasewas correlated with later puberty onset and earlier menopause in a study ofmigrant women, possibly suggesting an adaptive... →

Early-life experiencere-organizes neuromodulatory regulation of developmental patterns of behaviorand individuality   Early-life experiences may promote robust and long-lastingbehavioral outputs within populations, but also patterns of behavioralresponses that are variable among individuals, even... →

Decipheringthe role of alanine as a novel metabolic regulator of T cell immunity Abstract:T lymphocytes survey our body for threats. Under homeostasis, thesecells rarely proliferate. Upon encountering their cognate antigen and... →

The seminar will be given Hybrid: In the Faculty of Biology Auditorium and in ZOOM:https://technion.zoom.us/j/98596900607?pwd=UXk4eWk5dmZPOUFuMEl2Q1dCZ2puUT09Meeting ID: 985 9690 0607Passcode: 845596.Research Topic:Selection for resistance in marine cyanobacteria against generalist and specialist phages →

Title: Studying RNA Binding Proteins at Subcellular Resolution to Uncover their Roles in Health and Dysregulation in Disease Zoom: https://technion.zoom.us/j/96006672617 Abstract: Regulation of gene expression is at the basis of cell function.... →

Tcell starvation and nutrient competition at the tumor micro environment is considered a major limiting factor in cancer immunotherapy. Metabolic suppression hampers T cell activation, differentiation, and effector functions, leading... →

Title: Hair Raising Tale: Nerve – Stem Cell Interactions Zoom: https://technion.zoom.us/j/95140358269 Abstract: Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle, and the sympathetic nerve, providing a model to... →

Title: Filamentous actin drives nuclear architectural changes to maintain genome stability ZOOM:  https://technion.zoom.us/j/91878900904 Abstract: Cell proliferation requires efficient and accurate DNA replication. The complexity of replication, however, renders genome copying susceptible to endogenous... →

Title: The importance of being in the membraneZoom Link: :  https://technion.zoom.us/j/95594834686Abstract: With in cell membranes are numerous proteins and protein complexes that are responsible for the execution of a multitude of functions essential... →

Title: The diverse cellular and molecular mechanisms driving neuronal and axonal degenerationZoom: https://technion.zoom.us/j/98391777547Abstract: Aberrations in protein folding, processing and degradation are common features of neurodegenerative diseases, resulting in their accumulation. Amyotrophic lateral... →

Title: Toxoplasma gondii - a master manipulator: From effectordiscovery to novel concepts in cell death.Abstract: Toxoplasma gondii translocates effector proteins into its host cell tosubvert various host pathways. T. gondii effector TgIST blocks thetranscription... →

Antigen-SpecificImmunomodulation in Multiple Sclerosis by IL-10 -TCell Receptor-Like Antibodies (TCRL) Fusion ProteinsMultiple sclerosis (MS) is anautoimmune disease of the central nervous system (CNS) leading to demyelinationand disability. MS treatments are... →

Title: “Unravelling the microscale mechanisms driving particle degradation in the ocean”Abstract: The sinking of organic particles to the ocean depths is the main driving force of thebiological pump, the process... →

Regulation of mitochondrial trafficking by Myosin XIX during cell migration. Myosin XIX (Myo19) is an actin-based molecular motor that is anchored to the outer mitochondria membrane (OMM) via its unique... →

 Studying AlternativePolyadenylation in Human Cells and Clinical Samples during Human Cytomegalovirus (HCMV)Infection  HCMV infection is the leadingcause for congenital abnormalities in the western world. We studiedtranscriptomic changes in human fibroblast and... →

Title: What can fishes teach us about the brain?Abstract: Fishes have diverged in evolution from the mammalian linage some 450million years ago and as a result fishes’ brain structure is... →

Title: Golgi Redox and Gut Health: the Elegant Mechanism for ConstructingIntestinal MucusGuest: Deborah Fass, Departmentof Chemical and Structural Biology, WeizmannInstitute of Science AbstractThreats to the body’s physical integrity come in a... →

Title: Factors andmechanisms in mRNA localization and translationAbstract:The expression ofgenes into a functional unit is regulated at multiple steps, from the initial RNAtranscription, through its processing, intracellular localization, and finally... →

TitleSame organ, different place - conserved regulation of a transient stem-cellstate in the initiation of multiple root types AbstractPlantsadjust their post-embryonic growth in response to environmental cues by formingnew organs in... →