Seminars

Dear all,   Our next seminar will be given by Dr. Yaniv Elkouby from the Department of Developmental Biology and Cancer Research, Faculty of Medicine, The Hebrew University of Jerusalem.  ... →

Title: Uncovering Neuronal Plasticity Following Associative Memory in C. elegans Associative learning enables animals to link a conditioned stimulus, like an odor, with an unconditioned stimulus, such as reward or... →

Title: "Using various single-molecular assays to measure the passage of RNA polymerase along the DNA template in optical tweezers" Abstract: Transcription is the subsequent step in the gene expression process.... →

Dear all,   Our next seminar will be given by Prof. Yasmine Meroz from the School of Plant Science and Food Security and the Center for Physics and Chemistry of... →

Title: Mitochondria dynamic and its translocation during cellular stress conditions   Abstract Mitochondria dynamics, motility, and translocation to distinct cellular regions by cytoskeleton-based machinery are essential for adapting to eukaryote cells' physiological... →

We invite you to join us for an engaging informal symposium where we will present and explain this year's Nobel Prize-winning breakthroughs in the fields of Physics, Chemistry, and Medicine.... →

Untargeted screening for small-molecule enzyme inhibitors via high-throughput metabolomics OMICS-based screening offers a promising approach for untargeted drug discovery. Recently, mass-spectrometry metabolomics and proteomics was used for inferring drug mechanism... →

Abstract: Understanding the intricate mechanisms governing epidermal pattern formation, particularly within ectodermal appendages like hair follicles, is a key pursuit in developmental biology. Reciprocal interactions between mesenchymal and epithelial cells... →

In search of pancreatic beta cells with a regenerative potential Shiran Rachel Peretz   Depletion of β cell mass is a key characteristic of diabetes, impairing insulin production and glucose... →

Cell-cell fusion during C. elegans male tail morphogenesis Cell-cell fusion is an essential process in the development and formation of body structures. The nematode Caenorhabditis elegans serves as a good... →

The effect of cell-laden bioink preparation and 3D bioprinting process on cells and on tissue formation This study addresses challenges in cultivated meat (CM) research, driven by the increasing demand... →

Structure-function Relationships in fibril forming Antimicrobial peptide Amyloid-like fibrils formed by antimicrobial peptides (AMPs) and microbial toxins hold significant promise as novel antimicrobial therapeutics and targets for antivirulence strategies. This... →

Overcoming Metabolic T-Cell Suppression in Cancer Immunotherapy Using Metabolic Engineering Cancer immunotherapy has shown remarkable success in hematologic cancers but remains less effective against solid tumors due to metabolic suppression... →

Dear all,   Our next seminar will be given by Dr. Or Shahar from the MIGAL Galilee Research Institute, Tel-Hai Academic College.   Place and time: Biology auditorium, Monday 5/8 at 13:00.   Title: Cell-type-specific... →

Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma Background and Motivation: Lung cancer has the highest mortality rate among all types of cancer worldwide. Strikingly, the RNA-binding... →

Dear all,   This week we will have four short talks by recent winners of the “paper of the month” award. Joshua Hazan, Bester lab Integration of transcription regulation and... →

Dear all,   Our next seminar will be given by Prof. Ravid Straussman from the department of Molecular Cell Biology, Weizmann Institute.   Place and time: Biology auditorium, Monday 22/7 at... →

Rhodopsin-carotenoid complexes in marine microorganisms Microbial rhodopsins are retinal-bound, light-activated membranal proteins found in diverse aquatic microbes. In the ocean’s photic zone, >50% of microbes harbor a rhodopsin gene, potentially... →

Seasonality of infection: Dynamics of cyanophage abundances and infection of their hosts Marine cyanobacteria are photosynthetic bacteria that are estimated to be responsible for a quarter of the ocean net... →

Dear all,   Our next seminar will be given by Prof. Gal Markel, the Director of Davidoff Cancer Center, Co-founder & Chairman of Samueli Integrative Cancer Pioneering Institute & Deputy Director General, Rabin... →

Mixing up the colors of the seas: Phototrophy by antenna-containing rhodopsins in aquatic environments Rhodopsin-based phototrophy is one of the two known ways by which microorganisms harvest sunlight energy. More... →

Biond Biologics – From Discovery and Application of Innovative Science to Breakthrough Biological Drugs for Cancer Treatment Speaker: Dr. Tehila Ben Moshe, CEO, Co-Founder, and Chairperson of the company In... →

Novel fungal MAP kinase signalling in response to a host plant small-molecule signal in the Cochliobolus-maize interaction Our study aims to investigate the relationship between fungi and their plant hosts... →

    Our next seminar will be given by Dr. Mor Nitzan from the School of Computer Science and Engineering, The Hebrew University, Jerusalem.   Place and time: Biology auditorium, Monday 24/6 at 13:00.  ... →

Novel enhancers in transcriptional regulation of the gonadotropin genes The pituitary gland luteinizing hormone (LH) and follicle stimulating hormone (FSH) control gonadal development and function, their levels changing dramatically at... →

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The faculty seminar will be given by Dr. Oren Kolodny from the Department of Ecology, Evolution, and Behavior, Hebrew University of Jerusalem.   Place and time: Biology auditorium, Monday 17/6 at 13:00.   Title: The role of... →

Dear all,   Our next seminar will be given by Prof. Michael Blank from the Faculty of Medicine, Bar-Ilan University.   Place and time: Biology auditorium, Monday 10/6 at 13:00.   Title: SMURF2-mediated ubiquitin signaling in epigenetic... →

Dear all,   Our next seminar will be given by Prof. Noam Shomron from the Department of Cell and Developmental Biology, Tel-Aviv University.   Place and time: Biology auditorium, Monday 3/6 at 13:00.   Title: Seeking... →

Dear all,   Excited to open up the second semester Faculty of Biology Seminar Series. The opening seminar will be given by Prof. Sagi Snir from the Department of Evolutionary and Environmental Biology... →

Unraveling the Complexities of Fibril-Forming Antimicrobial Peptides: A Computational Exploration My research aims to explore and evaluate peptides capable of forming cross-α fibrillar structures. It introduces a grid-based energy estimation... →

Alanine – a metabolic liability ‘by choice’ Abstract: T lymphocytes, the cellular arm of the adaptive immune system, maintain host homeostasis and orchestrate an immune response to pathogens and internal... →

Invited Speakers : *Ori Avinoam Weizmann Institute of Science *Nicolas Brukman Technion *Yael Iosilevskii Technion *Meital Oren-Suissa Weizmann Institute of Science *Amir Sapir University of Haifa-Oranim   Please RSVP here: https://forms.gle/65JqCTiV6Ac27p1P6... →

Bridge to Industry A lecture series fostering collaboration between academia and industry. The Faculty of Biology is proud to present a series of meetings focused on groundbreaking research and innovation... →

The unique mechanisms that enable Chlorella ohadii to thrive in light intensities that are fatal to most photosynthetic organisms Although light is required for photosynthesis, too much light is harmful... →

Dear all, Our next seminar will be given by Prof. Oded Rechavi from the Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel-Aviv University.   Place and time: Biology auditorium, Monday... →

Title: Degradation of photosynthetic antennae by viral auxiliary metabolic proteins   Abstract: Cyabophage auxiliary metabolic genes have a direct and substantial effect on oceanic photosynthesis and primary productivity Cyanophages often... →

The Faculty of Biology will host our Graduate Students who won the prize for the outstanding "Paper Of The Month" in recent months at the Faculty of Biology: Ariel Chazan-... →

Identifying metabolic alterations and vulnerabilities in therapy-induced senescent cancer cells Cellular senescence, cell cycle arrest due to stress conditions, is a defense mechanism against accumulation of mutations and tumorigenesis. Therapy-induced... →

Dear all,   This week the seminar will be given by Prof. Itay Tirosh from the Department of Molecular Cell Biology a the Weizmann Institute of Science.   Place and time: Biology auditorium, Monday 11/3... →

Role of Amino-acyl tRNA synthetases in the regulation of translation of mRNAs encoding for enzymes in amino acid biosynthesis pathways Amino-acyl tRNA synthetases are enzymes that catalyse the aminoacylation reaction,... →

    This week the seminar will be given by Prof. Moshe Elkabets from the Department of Microbiology, Immunology, and Genetics at Ben-Gurion University.   Place and time: Biology auditorium, Monday 4/3 at 13:00.... →

The highly arborized PVD neuron has male-specific function and structure in C. elegans The link between sensory neuron morphology and function remains difficult to ascertain, particularly in complex organisms. The... →

Dear all,   This week the seminar will be given by Dr. Yaara Oren from the School of Medicine at Tel Aviv University.   Place and time: Biology auditorium, Monday 26/2 at 13:00.  ... →

Impact of pseudouridylation on mitochondrial tRNA recognition by cognate synthetase Mitochondrial tRNAs (mt-tRNAs) undergo an extensive post-transcriptional modification. One such common modification is pseudouridylation, the conversion of uridine to a... →

  Characterizing a role of RBM15B in  DNA Repair   DNA double-strand breaks (DSBs) are considered among the most cytotoxic DNA lesions. Cells utilize various DSB repair pathways, including homologous... →

Characterization of a Novel Macrophage Population with a Protective Potential Against Immune Attack in T1D Type 1 Diabetes (T1D) is an autoimmune disease that is characterized by insulin deficiency caused... →

Heme: A Novel Driver of Immune Aging Age-related morbidity, including the increased rate of infectious diseases, cancer, and autoimmune disorders, is driven by the decline in immune potency. The aged... →

Combining RNA- and protein-centric approaches to discover new functions of non-coding RNAs during stem cell differentiation Non-coding RNAs are at the interplay between transcription and post transcription regulation. Long non-coding... →

  Heliorhodopsins function in Gram-positive bacteria Rhodopsins are light sensing proteins that span across all kingdoms of life. They absorb light using retinal. As a response to light, rhodopsins can... →

Elucidating the mysterious ubiquitin ligase mechanism of Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Ubiquitination is a post-translational modification that has emerged as a key regulator of most cellular processes, ranging from subcellular... →

Prediction of Response to Immune Checkpoint Blockade Treatments Using Tumour Microenvironment Cellular Landscape Immune checkpoint blockade (ICB) treatments hold great promise in the realm of cancer therapy. However, they are... →

Identification and Characterization of Functional LncRNA  Regulation of Mitochondrial Respiration Carolina Khoury, Dr. Assaf C. Bester The central dogma of molecular biology traditionally emphasizes RNA's role as a messenger, bridging... →

  Foxl2 and Nr5a1 regulation in gonadotrope cells of the anterior pituitary   The mammalian reproductive system is regulated by gonadotrope cells in the anterior pituitary gland. These cells produce... →

CBDV modulates myeloid suppressor cells in the tumor microenvironment   During solid tumor progression, the tumor microenvironment (TME) evolves into a highly immunosuppressive milieu. Key players in the immunosuppressive environment... →

Identification of molecules which control in-vitro progenitor to endocrine cell differentiation of hESCs-derived pancreatic cells Type 1 diabetes is a chronic disease, caused by the loss of insulin-producing β-cells which... →

A novel cannabinoid reduces uterine hyperplasia caused by tamoxifen in mice Uterine hyperplasia is characterized by overgrowth of cells in the lining of the uterus, causing it to become thicker... →

Developing a nutrient-based formulation to attenuate muscle wasting Muscle atrophy causes weakness and disability in aging, inactivity, and in many diseases. This loss of muscle mass and strength is primarily... →

Title: Role of Myo19, an actin-based mitochondria motor, during collective cell migration.   Abstract: Cellular migration is essential for embryonic development, wound healing, immune defense, and angiogenesis, but it also... →

  Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth The folic acid cycle mediates the transfer of one-carbon (1C) units to support nucleotide biosynthesis. While the importance of... →

MyoIC's effect on nucleolar structure and organization Myosins are predominantly recognized for their role in muscle contraction and cellular cargo transport. Interestingly, one member of class IC myosin, MyolC16 (Nuclear... →

mRNAs Co-transport with Mitochondria in Neuronal Cells: Sequence Elements and Protein Factors Neurons are polarized cells with high energetic demands, which are highly dependent on localized translation of nuclear-encoded mRNAs.... →

Histone H2B ubiquitination in transcription regulation Abstract Post-translational modifications of histones play a central role in regulating all cellular processes requiring access to DNA. Cross-talk between histone modifications, in which... →

Scavenging singlet oxygen - A key to avoid photoinhibition   Light drives most life on earth as photosynthetic organisms convert it to a chemical energy. However, too much light causes... →

Silently Shaping Structure- Exploring the role of synonymous genetic coding in shaping the local protein backbone structure In the mid-20th century Christian Anfinsen, later Nobel Prize winner, showed that RNaseA... →

The immunomodulatory treasure-trove of the gut microbiota Emerging evidence demonstrates the pivotal role of gut microbes in shaping our immune system. Studies have shown a handful of immunomodulatory activities of... →

Dear Biology Faculty Students, We are excited to invite you to an exclusive meeting with a visionary leader in the healthtech field, and our esteemed Founding Director, Yona Vaisbuch, where... →

Sedimentary Ancient DNA as a tool to study Human Evolution   Viviane Slon1,2   Department of Anatomy and Anthropology and Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of... →

Imaging DNA damage and neuronal maintenance in live sleeping animals Abstract Sleep is vital for survival of all animals, ranging from jellyfish to fish and humans. Sleep improves brain performance,... →

No commitments: Planarian stem cells in regeneration and homeostasis Abstract Regeneration, the regrowth of missing organs, is a widespread survival strategy contributing to recovery from injury and disease. My lab... →

Prof. Jackie Schiller from the Faculty of Medicine in the Technion as part of the André Cohen Deloro Research Prize Ceremony. The Schiller lab studies cortical computation. →

Virulent and Antimicrobial Amyloids in Infections and Neurodegeneration   Meytal Landau   Amyloids are protein fibers with robust structures, which are known mainly in the context of neurodegenerative diseases yet... →

Structural snapshots of the cytosolic and mitochondrial mRNA translation machineries in kinetoplastids mRNA translation is a universally conserved process consisting on translating the genetic code into proteins. Translation is mainly... →

Immunoception: brain representation and control of peripheral immunity    Thoughts and emotions can impact physiology. This connection is evident in the emergence of disease following stress, psychosomatic disorders, or recovery... →

The Dance of the Amyloids: The Intricate Interactions of Pseudomonas aeruginosa Biofilm-Associated Amyloids FapB and FapC In my study, I delved into the intricate interactions of FapB and FapC, the... →

Eco-physiological research and wetland conservation: insights from pelican and cormorant studies in Israel.   The deterioration of wetlands resulting from global climate change, development, and habitat fractionation render long-distance migrating... →

Studying RNA transcription regulation via RNA-binding proteins   DRBP are proteins capable of binding DNA and RNA. Due to their dual capacity, those proteins can act at different steps of... →

Transcription Factors-RNA interaction: a new layer of cellular regulation Gene expression is a complex process tightly regulated by various proteins, including DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs). However, little... →

The ins and outs of meristem function and shape   Abstract:   Growth extent and direction determine cell and whole-organ architecture. How they are spatio-temporally coordinated across distinct cell types... →

A dual role of RBM42 in modulating splicing and translation during DNA damage response: A spotlight on CDKN1A/p21 gene   Abstract p53-mediated cell cycle arrest during DNA damage is dependent... →

Precise patterning in the inner ear   Abstract:   Precise periodic organization of cells is required for the function of many organs and tissues. It is often unclear, however, how... →

Estrogen Receptor Modulation by a Newly-Identified Phytocannabinoid in a Preclinical Model of Breast Cancer Breast cancer is made up of different subtypes that respond differently to treatments. Tumors that express... →

Characterization of Peroxismoal Proteins Changes in Response to Stress   Peroxisomes are organelles with a single bilayer membrane that encloses a soluble matrix space. Their importance is highlighted by the... →

Anti-cancer compounds from East Mediterranean seaweeds This project is aimed to study the anti-cancer effect of the East Mediterranean seaweeds to point out seaweeds of interest for future investigation and... →

  ISG15 and ISGylation at the ribosome: mechanistic analysis, innate immune response, and impact on translation   The innate immune response is the first line of defense against all pathogens.... →

Developing a single molecule approach to selective ribosome profiling   mRNA-protein interactions are at the center of the translation process. Ribosome-associated factors, from modifying enzymes to molecular chaperones, play a... →

Understanding the turnover of the truncated form of mutant ubiquitin UBB+1, UBBG76Y Ubiquitin is a 76 amino acid molecule that labels proteins for degradation. Its C-terminus at 76 glycine is... →

Reference-based deep examination of single-cell RNA-seq clusters Identifying the biological state of each single cell is arguably the most challenging task in scRNA-seq data analysis. Doing so requires bridging the... →

Title: comprehensive terminomic characterization of biological systems. Seminar abstract: Protein termini carry valuable information related to protein activity, localization, interaction and stability. Learning these various properties can be detrimental to... →

  Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression   During solid tumor progression, the tumor microenvironment (TME) evolves into a highly immunosuppressive... →

An Internal Model of Sensorimotor Context in Freely Swimming Electric Fish Internal models that predict the sensory consequences of motor actions are vital for sensory, motor, and cognitive functions. However,... →

Immunomodulation of EAE with Antibodies Targeting Autoreactive T-Cell Epitopes   Multiple sclerosis (MS) is a demyelinating autoimmune disease influencing more than 2.5 million people around the world. Damage caused in... →

The UPRmt coordinates mitochondrial network expansion and peroxisome biogenesis in the model organism Caenorhabditis elegans As organisms develop, individual cells generate mitochondria and peroxisomes to fulfill their physiological requirements. A... →

Oligodendrocyte plasticity in cognitive aging and neurodegeneration Abstract Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain aging.... →

Posters that were chosen as excellent in the departmental research days, will be presented by the graduate students. A panel of judges will choose the winning posters. A “Crowd Favorite”... →

Understanding the ancient evolution and function of innate immunity The human innate immune system has long been considered the result of extensive evolutionary innovations in metazoans. However, this dogma has... →

Study of Antigen Presentation and Antigen-Specific Immunomodulation in Multiple Sclerosis by T cell Receptor-mimic Antibodies During autoimmune diseases, like Multiple Sclerosis (MS), the immune system is downregulated in a non-specific... →

How One Eukaryotic Cell Invades Another: Dissecting Invasion by Apicomplexa The phylum Apicomplexa includes several of the most prevalent and important human eukaryotic pathogens, such as Plasmodium spp., which causes... →

Estrous cycle and Egg release resets inspired by neurodynamics in the circadian pacemaker   Jet lag and shift work disrupt the menstrual cycle and decrease fertility. The circadian pacemaker, the... →

The third lecture in the "Science Talk on the Bar" series of the Faculty of Biology About: • Is cannabis the antibiotics of the 21st century? • How many patients... →