23/10/2022 10:00
Faculty of Biology Auditorium, Technion-Israel Institute of Technology
10:00-10:30 - Gathering, coffee, and cakes 10:30-10:40 - Opening Remarks, Faculty Dean Yael Mandel Gutfreund 10:40-10:50 – Introduction, Yoram Reiter 10:50-11:20 - Michael Boshart, Genetics - Biocenter LMU, München Protein...
18/10/2022 13:00
hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j/98617011894
"The Antitumor Effects of Cannabinoids in Glioblastoma Multiforme" Glioblastoma multiforme is an aggressive brain tumor whose current treatments are insufficient due to its high invasiveness and heterogeneity, rapid growth and...
13/09/2022 13:30
hybrid- in the Faculty Auditorium/ZOOM
What mechanism protects the heart from fasting-induced atrophy? Skeletal muscles atrophy upon systemic fasting, when blood glucose and insulin levels are low. However, the heart is relatively protected, and atrophy...
13/09/2022 13:00
hybrid- in the Faculty Auditorium/ZOOM
Revealing Hormone-Mediated Tissue-Specific Nuclear Proteome and Signaling Output in the Meristem Our lab seeks to understand the principles underlying developmental programs in plants. Using roots as a model organ, we...
07/09/2022 13:00
hybrid- in the Faculty Auditorium/ZOOM
The Effect of Cannabinoids on Microglial Phagocytosis of Amyloid-beta: Implications for Alzheimer’s Disease During the progression of the neurodegenerative Alzheimer’s disease, amyloid-β peptides accumulate in the brain to form toxic...
06/09/2022 13:00
Biology auditorium
Title: Linking learning to behaviour via neural representation geometry. Abstract: Recent developments in experimental neuroscience enable us to simultaneously record the activity of a large number of neurons and to...
30/08/2022 13:00
Programmed Cell Death RegulatesSebaceous Gland Homeostasis and Pathology   In the past decade, most studies investigating mammalian skin havefocused on the epidermis and the hair follicle, whereas much less is...
23/08/2022 13:00
Apoptoticcells represent a dynamic stem cell niche governing proliferation and tissueregeneration   Summery Stem cells (SCs) play a key role inhomeostasis and repair. While many studies have focused on SC...
22/08/2022 13:00
Roles of Aminoacyl tRNA synthetases in mRNA regulation Aminoacyl tRNA synthetases (aaRSs) are a well-studied family of enzymes with a canonical role in charging tRNA with specific amino acid. Yet,...
15/08/2022 13:00
Studying the functionalsignificance of RNA editing and duplicated genomic regions in Caenorhabditiselegans RNAediting is a phenomenon of RNA sequence alteration after transcription ineukaryotes. In mammals, the most common alterations studied...
09/08/2022 13:30
Shape readout by the transcription factor ETS1 of its RE's   Transcription in eukaryotes is under the control oftranscription factors (TFs) binding to specific DNA binding sites. ETS proteinsare a...
09/08/2022 13:00
Research subject: The role of caspase-9 in hairfollicle stem cells. Summary: Programed cell death(PCD) serves many important functions in mammalian development and tissuehomeostasis. These include shaping tissue morphology during organogenesis...
02/08/2022 13:00
  The mechanistic origin of p53 selectivity and functionalityOne of the master transcriptional regulation hubs of every human cell is the transcription factor (TF) p53 protein. p53 is activated in...
26/07/2022 13:30
 “CRISPRscreen to identify lncRNA genes critical for SARS-CoV-2 infection” Coronavirus disease(COVID-19) is caused by the infection of Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2). The viral entry into host cells is mediated...
26/07/2022 13:00
 Throughoutthe last number of years, the non-protein-coding portion of the human genomehas gone from being considered “junk DNA” to “hot spots” in the area of lifescience. Genome-wide transcriptome studies indicate...
04/07/2022 13:00
Learn about great options in the industry at the interface of biologyand computer science Martin Akerman is a Technion Alumni who completed his undergraduate and  PhD at the Faculty of Biology....
28/06/2022 13:00
Time: Thursday June 28th 13:00Place: hybrid- in the Faculty Auditorium/ZOOMhttps://technion.zoom.us/j/97658538324The HLA Peptidome of Lung Cancer: Towards the Developmentof Personalized ImmunotherapyLung cancer is the leading cause of cancer-related death worldwide, mainly...
27/06/2022 13:00
Title: Spatial transcriptomics ofmammalian tissuesAbstract: Mammaliantissues are composed of repeating anatomical units that are polarized bymorphogens or directional blood flow. As a result, cells at different tissuecoordinates sub-specialize in distinct physiological functions,...
20/06/2022 13:00
Title: Thinking outsidethe mouse: ex-vivo dissections of host-microbiome cross-talksKey points: ·        We developed a novel 3D gut organ culture system, as a uniquetool for studying host-microbiome interactions.·        Enteric neuro-immune-microbiome cross-talks control regulatoryand effector T-cells...
13/06/2022 13:00
Title: Rethinking Mammalian Embryonic Development: An Integrated View of Epigenetics and Cell CommitmentAbstract:One of the mostremarkable processes in biology is the development of a single fertilized egginto a complete multi-cellular embryo...
06/06/2022 13:00
Title:Activity Homeostasis in Neural Circuits: From Basic Principles to MalfunctionsAbstract:Maintaining averageactivity level within a set-point range constitutes a fundamentalproperty of central neural circuits. Accumulated evidence suggests that firingrate distributions and their means represent...
30/05/2022 13:00
Title: The power of ONE:Immunology in the age of single cell genomicsAbstract:The immune system is a complex, dynamic and plastic networkcomposed of various interacting cell types that are constantly sensing andresponding...
25/05/2022 13:00
Title: Innate immunity infungi: Is regulated cell death involved?Host: Benjamin Horwitz
23/05/2022 13:00
Title: From the Egg to the Kidney… and BackAbstract:Whatconnects the union of gametes at fertilization, a fundamental processthat ensures the transmission of genetic material through the generations, tothe defense against pathogens...
17/05/2022 13:00
Time: Tuesday May 17, 2022, 13:00 PMPlace: Hybrid – The Faculty og Biology AuditoriumZOOM: https://technion.zoom.us/j/91251316715Functional Super Molecular Structures of Self-assembled ProteinsAntimicrobial peptides are secreted by the innate immune system of...
16/05/2022 13:00
Title: New insights intoperoxisomes - small organelles with exciting biology and a huge impact on humanhealth.Abstract: Peroxisomes arecentral metabolic organelles whose decreased function gives rise to severe peroxisomaldiseases. It is recently becoming...
09/05/2022 13:00
Title: Physiological mechanisms of brain-body interactions Host: Sagi Levy
02/05/2022 13:00
Title: Decoding uniquitin signalsAbstract:UbiquitinE3-ligases regulate most of the cellular pathways and consequently are tightlyregulated themselves. Several allosteric mechanisms for regulation of HECTE3-ligases that were identified and characterized in our lab...
25/04/2022 13:00
Title: Nano drug delivery Host: Sagi Levy
11/04/2022 14:30
Title: The regulatory role of free ISG15Interferons(IFNs) are a group of cytokinesinduced by viral infection. IFN production leads to a series of protein conformationalrearrangements and interactions as well as production...
11/04/2022 13:00
Title: Howtranscription factors recognize binding sites in large genomes: the role ofintrinsically disordered regions.  Abstract:Transcription factors (TFs) regulate geneexpression by binding DNA sequences recognized by their DNA-binding domains (DBDs).DBD-recognized motifs...
07/04/2022 12:30
Place: hybrid- inthe Faculty Auditorium/ZOOM:https://technion.zoom.us/j/93473479861The role of pregnancy in skin regenerationAbstract: The physiology of mammalian skin changesdramatically during pregnancy due to immunological, metabolic, and hormonalshifts. Estrogens are major regulators of...
05/04/2022 14:30
Title:  Tracking the development and assembly of single cellsAbstract:  While high-throughput methods provide a sweepingbirds-eye view of development, different insights can be gained by zooming into study how a single cell...
04/04/2022 13:00
Title: Cis-acting gene regulationby long noncoding RNAs.  Abstract:It is now clear that many intergenic regions in eukaryoticgenomes give rise to a range of processed and regulated transcripts that do notappear...
28/03/2022 13:00
The ‘Hunger Games’- Structural Studies of the MC4 Receptor Reveal Mechanism for SatietyHost: Sagi LevyAbstract: Obesity is aglobal epidemic causing increased morbidity and impaired quality of life. Themelanocortin receptor 4 (MC4R)...
22/03/2022 13:00
Systematicidentification of gene-altering programmed inversions across the bacterialdomain Programmedchromosomal inversions allow bacteria to generate intra-population genotypicand functional heterogeneity, a bet-hedging strategy important in changingenvironmental challenges, such as bacteriophages and antibiotic drugs....
21/03/2022 13:00
Title: Anti-tumor antibodies in ovarian cancer patients. Host: Sagi Levy
16/03/2022 13:00
Underlying mechanisms of re-programingreproduction following early life adversityA high burden of inflammatory diseasewas correlated with later puberty onset and earlier menopause in a study ofmigrant women, possibly suggesting an adaptive...
09/03/2022 13:30
Early-life experiencere-organizes neuromodulatory regulation of developmental patterns of behaviorand individuality   Early-life experiences may promote robust and long-lastingbehavioral outputs within populations, but also patterns of behavioralresponses that are variable among individuals, even...
09/03/2022 13:00
Decipheringthe role of alanine as a novel metabolic regulator of T cell immunity Abstract:T lymphocytes survey our body for threats. Under homeostasis, thesecells rarely proliferate. Upon encountering their cognate antigen and...
02/02/2022 13:00
The seminar will be given Hybrid: In the Faculty of Biology Auditorium and in ZOOM:https://technion.zoom.us/j/98596900607?pwd=UXk4eWk5dmZPOUFuMEl2Q1dCZ2puUT09Meeting ID: 985 9690 0607Passcode: 845596.Research Topic:Selection for resistance in marine cyanobacteria against generalist and specialist phages
31/01/2022 13:00
In hybird format: Auditorium + zoom
Title: Studying RNA Binding Proteins at Subcellular Resolution to Uncover their Roles in Health and Dysregulation in Disease Zoom: https://technion.zoom.us/j/96006672617 Abstract: Regulation of gene expression is at the basis of cell function....
26/01/2022 13:00
Faculty of Bilogy Auditorium
Tcell starvation and nutrient competition at the tumor micro environment is considered a major limiting factor in cancer immunotherapy. Metabolic suppression hampers T cell activation, differentiation, and effector functions, leading...
24/01/2022 13:00
In hybrid format: Auditorium + Zoom - https://technion.zoom.us/j/95140358269
Title: Hair Raising Tale: Nerve – Stem Cell Interactions Zoom: https://technion.zoom.us/j/95140358269 Abstract: Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle, and the sympathetic nerve, providing a model to...
17/01/2022 13:00
In hybrid format: Auditorium + Zoom (see link below)
Title: Filamentous actin drives nuclear architectural changes to maintain genome stability ZOOM:  https://technion.zoom.us/j/91878900904 Abstract: Cell proliferation requires efficient and accurate DNA replication. The complexity of replication, however, renders genome copying susceptible to endogenous...
10/01/2022 13:00
Title: The importance of being in the membraneZoom Link: :  https://technion.zoom.us/j/95594834686Abstract: With in cell membranes are numerous proteins and protein complexes that are responsible for the execution of a multitude of functions essential...
03/01/2022 13:00
Title: The diverse cellular and molecular mechanisms driving neuronal and axonal degenerationZoom: https://technion.zoom.us/j/98391777547Abstract: Aberrations in protein folding, processing and degradation are common features of neurodegenerative diseases, resulting in their accumulation. Amyotrophic lateral...
27/12/2021 13:00
Title: Toxoplasma gondii - a master manipulator: From effectordiscovery to novel concepts in cell death.Abstract: Toxoplasma gondii translocates effector proteins into its host cell tosubvert various host pathways. T. gondii effector TgIST blocks thetranscription...
22/12/2021 13:00
Antigen-SpecificImmunomodulation in Multiple Sclerosis by IL-10 -TCell Receptor-Like Antibodies (TCRL) Fusion ProteinsMultiple sclerosis (MS) is anautoimmune disease of the central nervous system (CNS) leading to demyelinationand disability. MS treatments are...
20/12/2021 13:00
Title: “Unravelling the microscale mechanisms driving particle degradation in the ocean”Abstract: The sinking of organic particles to the ocean depths is the main driving force of thebiological pump, the process...
15/12/2021 13:30
Regulation of mitochondrial trafficking by Myosin XIX during cell migration. Myosin XIX (Myo19) is an actin-based molecular motor that is anchored to the outer mitochondria membrane (OMM) via its unique...
15/12/2021 13:00
 Studying AlternativePolyadenylation in Human Cells and Clinical Samples during Human Cytomegalovirus (HCMV)Infection  HCMV infection is the leadingcause for congenital abnormalities in the western world. We studiedtranscriptomic changes in human fibroblast and...
13/12/2021 13:00
Title: What can fishes teach us about the brain?Abstract: Fishes have diverged in evolution from the mammalian linage some 450million years ago and as a result fishes’ brain structure is...
06/12/2021 13:00
Title: Golgi Redox and Gut Health: the Elegant Mechanism for ConstructingIntestinal MucusGuest: Deborah Fass, Departmentof Chemical and Structural Biology, WeizmannInstitute of Science AbstractThreats to the body’s physical integrity come in a...
22/11/2021 13:00
Title: Factors andmechanisms in mRNA localization and translationAbstract:The expression ofgenes into a functional unit is regulated at multiple steps, from the initial RNAtranscription, through its processing, intracellular localization, and finally...
15/11/2021 13:00
TitleSame organ, different place - conserved regulation of a transient stem-cellstate in the initiation of multiple root types AbstractPlantsadjust their post-embryonic growth in response to environmental cues by formingnew organs in...
08/11/2021 13:00
Title: Themulti-scale structure of chromatin in the nucleus Host: Sagi Levy
08/11/2021 13:00
The multi-scale structure of chromatin in the nucleusYuval GariniBiomedical Engineering Faculty,TechnionYuval.garini@technion.ac.il  ,  www.garini-lab.com/  The DNA in a human cell which is ~3 meters long is packed in a ~10 μmradius...
27/10/2021 13:00
“Computational approach to identifynew roles for long non-coding RNAs involved in pluripotency anddifferentiation” ecently long non coding RNAs (lncRNAs) have emerged asregulators of pluripotency and differentiation, however their contribution tospecific...
27/10/2021 13:00
“Computational approach to identify new roles for long non-coding RNAs involved in pluripotency and differentiation”Recently long non coding RNAs (lncRNAs) have emerged as regulators of pluripotency and differentiation, however their...
25/10/2021 13:00
DNA dynamicsdictates p53 functional outcomeTali E. Haran AbstractThe tumor suppressor protein p53 issituated in the midst of a complex cellular network that is activated inresponse to cellular stress. Activated p53 functions...
25/10/2021 13:00
DNA dynamicsdictates p53 functional outcomeTali E. Haran AbstractThe tumor suppressor protein p53 issituated in the midst of a complex cellular network that is activated inresponse to cellular stress. Activated p53 functions...
12/10/2021 13:00
Abstract:RNA editing is a highly conserved mechanism by which theAdenosine Deaminases Acting on RNA (ADAR) enzymes convert adenosines (A) intoinosines (I), which are recognized by the splicing and translationalmachineries as...
12/10/2021 13:00
Abstract:RNA editing is a highly conserved mechanism by which theAdenosine Deaminases Acting on RNA (ADAR) enzymes convert adenosines (A) intoinosines (I), which are recognized by the splicing and translationalmachineries as...
17/08/2021 13:00
A Computational Pipeline for the Quantification of Social Interactions Across DevelopmentLittle is known about how social behavior changes across different stages of development in animals. The nematode C. elegans offers...
17/08/2021 13:00
A Computational Pipeline for the Quantification of Social Interactions Across DevelopmentLittle is known about how social behavior changes across different stages of development in animals. The nematode C. elegans offers...
21/07/2021 13:00
Whilemobile genetic elements play a consequential part in bacterial adaptation andantibiotic resistance, relatively little is known about their role inwithin-host pathogen evolution. To explore their function, we constructed acomputational pipeline...
20/07/2021 13:00
Researchtopic: The dualrole of a cyanophage thioredoxinAbstract:Marinecyanobacteria are highly abundant photosynthetic organisms that contributegreatly to global primary production. Their viruses, marine cyanophages, arealso extremely abundant and have a major effect...
14/07/2021 13:00
Anchoredcells of the basal epidermis constantly undergo proliferation in an overcrowdedenvironment. One important regulator of epidermal proliferation is YAP, whichcan be controlled by both cell-matrix and cell-cell interactions. During myPh.D.,...
06/07/2021 13:00
Stem Cells: a Matter of Life and DeathStemcells ( play a pivotal role in fueling homeostasis and regeneration Whilemuch focus has been given to self renewal and differentiation pathways regulatingSC...
29/06/2021 13:00
 The development and growth of the plant body are regulated by aninterplay between plant hormone signaling pathways that both interpret anddetermine their accumulation and distribution. Brassinosteroids (BRs) are oneof these...
28/06/2021 13:00
Title: Improving T cell effector functionsby limiting mitochondrial-derived ATP transfer to the cytosolHost: Noga Ron Harel & Ayala Shiber Zoom: https://technion.zoom.us/j/93293373229
22/06/2021 14:30
Title: "A novel microfluidic assay foradhesion-free migration reveals a polarized motility mode"Abstract:Cell motility is a key factor in various processes such ascancer metastasis, immune response, and wound healing.  The mode ofcell...
21/06/2021 13:00
Title: “Understanding the systemic control of proteostasis”Host: Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
15/06/2021 13:00
The regulation of Tet1 by steroidhormones in proliferating gonadotrope precursor cellsThe hydroxymethylase, Tet1, plays amajor role in regulating gene expression, and its knockdown specificallyaffects fertility. Reproductive function is activated by...
14/06/2021 13:00
Title: Unicellularand multicellular stress responses in bacterial biofilmsHost: Roy Kisony & Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
08/06/2021 13:00
Community-associated methicillin-resistant Staphylococcusaureus (CA-MRSA) has spread worldwide and is threatening public health. Itshallmark is the mecA gene, whichconfers resistance to nearly all β-lactam antibiotics. However, it is unknownwhether mecA provides...
07/06/2021 13:00
Seminarin memory of Prof. Dan Tawfik -“thedynamics and molecular mechanisms of microbial evolution”Host:  Ayala ShiberZoom https://technion.zoom.us/j/93293373229
31/05/2021 13:00
Title: “Structural and energy-based modeling of protein complexes: biotechnological applications ”Host: FabianGlasser& Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
24/05/2021 13:00
Title:Invivo Multi Scale Imaging of Vascular-Immune Interactions in CardiovascularDisease”Host: Dvir Aran & Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
11/05/2021 13:00
, " Evolutionary paths tohigh-level ampicillin resistance ""  Thewidespread use of beta-lactams has resulted in a growing prevalence of highlyresistant pathogens.Indeed, clinical isolates can have very high resistance to beta-lactams, mostprominently...
10/05/2021 13:00
Title: Theevolution of a complex morphology at a single-cell resolution”Host: Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
03/05/2021 13:00
Title: “KeepingTime with TranscriptionHost: Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
27/04/2021 13:00
Mechanisms of chemoresistance in relapsed AMLpatients: towards efficacious precision medicineAcutemyeloid leukemia (AML) remains a devastating disease with a 5-year survivalrate of less than 30%. AML treatment has undergone significant advances...
20/04/2021 14:30
Research Topic: Mass spectrometry approaches for studying cancermetabolism  Mass spectrometry based metabolomics is a widely usedapproach in biomedical research. However, current methods coupling massspectrometry with chromatography (LC-MS) are time-consuming and...
19/04/2021 13:00
Title: Weight loss dependentand independent effects of weight-loss surgery    Host: Sagi Levy & Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
12/04/2021 13:00
Title:“Implementing logic gates in cancer immunotherapy    ”Host: OfirLevin-Piaeda& Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
05/04/2021 13:00
Title:  "The Cys Sensing: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins" Host: Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
25/03/2021 13:00
Title:“Researchin the data-rich biomedical era to advance precision medicine”Host: Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
03/03/2021 13:00
An ordered loss ofdesminfilaments precedesand promotes muscle atrophyMyofibril breakdown is a hallmarkof muscle wasting and an inevitable sequel of aging and disease. The desmincytoskeleton is critical for skeletal muscle architecture...
17/02/2021 13:00
BiophysicalProperties that Influence Optimal Functional Output of TCR Engineered T Cells Theencounter of the TCR with its cognate peptide-MHC complex (pMHC) is a crucialstep in T-cell activation. One of the most...
10/02/2021 13:00
Insulinreceptor turnover in fasting is dependent on b-dystroglycan deglycosylationFasting exertsvarious physiological effects, most notably, reduced signaling through theinsulin receptor. Insulin receptor activity requires association withDystrophin Glycoprotein Complex (DGC), and fasting...
02/02/2021 12:00
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took...
27/01/2021 13:00
Title:Structure-function analysis of EFF-1 mediated cell-cell fusion Cell-cellfusion is a universal multi-step process essential for organogenesis and sexualreproduction. EFF-1 protein and its paralog AFF-1 are necessary and sufficientfor fusion in the...
25/01/2021 13:00
Title: “The HLA peptidome – its cellular production pipeline andclinical usefulness”Host: Ayala Shiberhttps://technion.zoom.us/j/96789984896
20/01/2021 13:00
Characterizing the auxiliarynucleotide binding sites in RecBCDDNA helicase, towards deciphering their functional roleAbstract:RecBCD is aDNA helicase-nuclease, powering the initiation of dsDNA break repair. It is ahighly processive fast helicase, with...
18/01/2021 13:00
Title: TBAHost: Ayala Shiberhttps://technion.zoom.us/j/91816487260    
13/01/2021 13:00
TitleA single molecule study of protein-DNAinteractionsAbstract Bindingof transcription factors (TFs) to regulatory regions in the genome is crucialfor the initiation of transcription, and thus one of the most important layersin...
11/01/2021 13:00
Title: “Lost in Translation: the Ribosomal Epitranscriptome in Hematopoiesis” Host: Ayala Shiber ZOOM
04/01/2021 13:00
Title: Investigatingthe cell biology of plant infection by the rice blast fungus MagnaportheoryzaeHost: Ayala Shiber
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