Seminars

Dear Biology Faculty Students, We are excited to invite you to an exclusive meeting with a visionary leader in the healthtech field, and our esteemed Founding Director, Yona Vaisbuch, where... →

No commitments: Planarian stem cells in regeneration and homeostasis Abstract Regeneration, the regrowth of missing organs, is a widespread survival strategy contributing to recovery from injury and disease. My lab... →

Prof. Jackie Schiller from the Faculty of Medicine in the Technion as part of the André Cohen Deloro Research Prize Ceremony. The Schiller lab studies cortical computation. →

Virulent and Antimicrobial Amyloids in Infections and Neurodegeneration   Meytal Landau   Amyloids are protein fibers with robust structures, which are known mainly in the context of neurodegenerative diseases yet... →

Structural snapshots of the cytosolic and mitochondrial mRNA translation machineries in kinetoplastids mRNA translation is a universally conserved process consisting on translating the genetic code into proteins. Translation is mainly... →

Immunoception: brain representation and control of peripheral immunity    Thoughts and emotions can impact physiology. This connection is evident in the emergence of disease following stress, psychosomatic disorders, or recovery... →

The Dance of the Amyloids: The Intricate Interactions of Pseudomonas aeruginosa Biofilm-Associated Amyloids FapB and FapC In my study, I delved into the intricate interactions of FapB and FapC, the... →

Eco-physiological research and wetland conservation: insights from pelican and cormorant studies in Israel.   The deterioration of wetlands resulting from global climate change, development, and habitat fractionation render long-distance migrating... →

Studying RNA transcription regulation via RNA-binding proteins   DRBP are proteins capable of binding DNA and RNA. Due to their dual capacity, those proteins can act at different steps of... →

Transcription Factors-RNA interaction: a new layer of cellular regulation Gene expression is a complex process tightly regulated by various proteins, including DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs). However, little... →

The ins and outs of meristem function and shape   Abstract:   Growth extent and direction determine cell and whole-organ architecture. How they are spatio-temporally coordinated across distinct cell types... →

A dual role of RBM42 in modulating splicing and translation during DNA damage response: A spotlight on CDKN1A/p21 gene   Abstract p53-mediated cell cycle arrest during DNA damage is dependent... →

Precise patterning in the inner ear   Abstract:   Precise periodic organization of cells is required for the function of many organs and tissues. It is often unclear, however, how... →

Estrogen Receptor Modulation by a Newly-Identified Phytocannabinoid in a Preclinical Model of Breast Cancer Breast cancer is made up of different subtypes that respond differently to treatments. Tumors that express... →

Characterization of Peroxismoal Proteins Changes in Response to Stress   Peroxisomes are organelles with a single bilayer membrane that encloses a soluble matrix space. Their importance is highlighted by the... →

Anti-cancer compounds from East Mediterranean seaweeds This project is aimed to study the anti-cancer effect of the East Mediterranean seaweeds to point out seaweeds of interest for future investigation and... →

  ISG15 and ISGylation at the ribosome: mechanistic analysis, innate immune response, and impact on translation   The innate immune response is the first line of defense against all pathogens.... →

Developing a single molecule approach to selective ribosome profiling   mRNA-protein interactions are at the center of the translation process. Ribosome-associated factors, from modifying enzymes to molecular chaperones, play a... →

Understanding the turnover of the truncated form of mutant ubiquitin UBB+1, UBBG76Y Ubiquitin is a 76 amino acid molecule that labels proteins for degradation. Its C-terminus at 76 glycine is... →

Reference-based deep examination of single-cell RNA-seq clusters Identifying the biological state of each single cell is arguably the most challenging task in scRNA-seq data analysis. Doing so requires bridging the... →

Title: comprehensive terminomic characterization of biological systems. Seminar abstract: Protein termini carry valuable information related to protein activity, localization, interaction and stability. Learning these various properties can be detrimental to... →

  Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression   During solid tumor progression, the tumor microenvironment (TME) evolves into a highly immunosuppressive... →

An Internal Model of Sensorimotor Context in Freely Swimming Electric Fish Internal models that predict the sensory consequences of motor actions are vital for sensory, motor, and cognitive functions. However,... →

Immunomodulation of EAE with Antibodies Targeting Autoreactive T-Cell Epitopes   Multiple sclerosis (MS) is a demyelinating autoimmune disease influencing more than 2.5 million people around the world. Damage caused in... →

The UPRmt coordinates mitochondrial network expansion and peroxisome biogenesis in the model organism Caenorhabditis elegans As organisms develop, individual cells generate mitochondria and peroxisomes to fulfill their physiological requirements. A... →

Oligodendrocyte plasticity in cognitive aging and neurodegeneration Abstract Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain aging.... →

Posters that were chosen as excellent in the departmental research days, will be presented by the graduate students. A panel of judges will choose the winning posters. A “Crowd Favorite”... →

Understanding the ancient evolution and function of innate immunity The human innate immune system has long been considered the result of extensive evolutionary innovations in metazoans. However, this dogma has... →

Study of Antigen Presentation and Antigen-Specific Immunomodulation in Multiple Sclerosis by T cell Receptor-mimic Antibodies During autoimmune diseases, like Multiple Sclerosis (MS), the immune system is downregulated in a non-specific... →

How One Eukaryotic Cell Invades Another: Dissecting Invasion by Apicomplexa The phylum Apicomplexa includes several of the most prevalent and important human eukaryotic pathogens, such as Plasmodium spp., which causes... →

Estrous cycle and Egg release resets inspired by neurodynamics in the circadian pacemaker   Jet lag and shift work disrupt the menstrual cycle and decrease fertility. The circadian pacemaker, the... →

The third lecture in the "Science Talk on the Bar" series of the Faculty of Biology About: • Is cannabis the antibiotics of the 21st century? • How many patients... →

Archaeal origins of gamete fusion Sexual reproduction consists of genome reduction by meiosis and subsequent gamete fusion. Fusexins, are a superfamily of structurally conserved proteins (fusogens) that mediate three types... →

Abstract: The fact that some amino acid chains fold alone into natively structured and fully functional proteins in solution, has led to the commonly accepted “one sequence-one structure” notion. However,... →

Arie Admon@70 symposia – Celebrating Arie's 35 years of Science "My Life with Mass Spectrometers, Proteomics, and Immunopeptidomics” Thursday, December 22, 2022; 10:00-15:00 Faculty of Biology Auditorium, Technion-Israel Institute of... →

Abstract: What are "Light Sensing" proteins and how were they discovered in the waters of the Sea of Galilee, for the first time since 1971? What is "harvesting solar energy",... →

Tales from the crypt: on helminth regulation of the stem cell compartment Abstract: Intestinal helminths remain pervasive throughout the animal kingdom by manipulating host defense pathways to prioritize tissue adaptation... →

Abstract All cells have evolved the means to store energy and thereby minimize the effects of fluctuations in nutrient availability. Cells store energy in the form of neutral lipids, such... →

During December, the faculty will hold a series of "Science TALKS over the counter" led by faculty PI in selected locations throughout Haifa and the north district. We are thrilled... →

  Reducing scRNA-seq data via nonnegative matrix factorization for annotation and clustering analysis abstract: Single-cell RNA sequencing (scRNA-seq) provides an unprecedented opportunity to dissect tissue heterogeneity and characterize individual cells.... →

Abstract Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain aging. Cerebrospinal fluid (CSF) makes up the immediate... →

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  https://en.globes.co.il/en/article-genome-sequencing-co-ultima-genomics-raises-600m-1001414037   Genome sequencing company Ultima Genomics has come out of stealth and announced $600 million in financing. Founded in 2016 by its Israeli CEO Gilad Almogy, the company... →

Tales of protein tails and the proteases that generate them Proteolysis is one of the mechanisms that allows cells to alter their proteome in response to different conditions or signals.... →

  Thermodynamic models for the homeostasis and development of the epidermis and spherical organoids Epithelial tissues formed of layered cell surfaces are prevalent in multiple tissues and play an essential... →

Abstract: Cellular plasticity is emerging as an important driving force underlying cancer progression and drug resistance. In this talk, I will discuss the concept of cancer cell states present in... →

Abstract:   The formal scientific method tells you how to rigorously and objectively test a hypothesis. But where do hypotheses come from in the first place? Posing fruitful new questions,... →

The Ayoub lab studies DNA damage repair, genome stability and cancer. Ayoub lab: http://ayoubn.net.technion.ac.il/ →

Graph Theory Approaches for Network Analysis of Neuronal Signals and Behavior How does the brain encode behavior? What are the internal mechanisms affecting neuronal network organization and configuration at different... →

Adult stem cells (SCs) are tissue-specific resident cells that serve to replenish and maintain the tissue. Two significant SC populations co-exist in the hair follicle: hair follicle SCs (HFSCs) and... →

Exocytosis by membrane crumpling maintains homeostasis during exocrine secretion Dynamic membrane remodeling is essential for life. Cells, organelles, and vesicles must constantly acquire, maintain and modify their shape and composition... →

10:00-10:30 - Gathering, coffee, and cakes 10:30-10:40 - Opening Remarks, Faculty Dean Yael Mandel Gutfreund 10:40-10:50 – Introduction, Yoram Reiter 10:50-11:20 - Michael Boshart, Genetics - Biocenter LMU, München Protein... →

"The Antitumor Effects of Cannabinoids in Glioblastoma Multiforme" Glioblastoma multiforme is an aggressive brain tumor whose current treatments are insufficient due to its high invasiveness and heterogeneity, rapid growth and... →

What mechanism protects the heart from fasting-induced atrophy? Skeletal muscles atrophy upon systemic fasting, when blood glucose and insulin levels are low. However, the heart is relatively protected, and atrophy... →

Revealing Hormone-Mediated Tissue-Specific Nuclear Proteome and Signaling Output in the Meristem Our lab seeks to understand the principles underlying developmental programs in plants. Using roots as a model organ, we... →

The Effect of Cannabinoids on Microglial Phagocytosis of Amyloid-beta: Implications for Alzheimer’s Disease During the progression of the neurodegenerative Alzheimer’s disease, amyloid-β peptides accumulate in the brain to form toxic... →

Title: Linking learning to behaviour via neural representation geometry. Abstract: Recent developments in experimental neuroscience enable us to simultaneously record the activity of a large number of neurons and to... →

Programmed Cell Death RegulatesSebaceous Gland Homeostasis and Pathology   In the past decade, most studies investigating mammalian skin havefocused on the epidermis and the hair follicle, whereas much less is... →

Apoptoticcells represent a dynamic stem cell niche governing proliferation and tissueregeneration   Summery Stem cells (SCs) play a key role inhomeostasis and repair. While many studies have focused on SC... →

Roles of Aminoacyl tRNA synthetases in mRNA regulation Aminoacyl tRNA synthetases (aaRSs) are a well-studied family of enzymes with a canonical role in charging tRNA with specific amino acid. Yet,... →

Studying the functionalsignificance of RNA editing and duplicated genomic regions in Caenorhabditiselegans RNAediting is a phenomenon of RNA sequence alteration after transcription ineukaryotes. In mammals, the most common alterations studied... →

Shape readout by the transcription factor ETS1 of its RE's   Transcription in eukaryotes is under the control oftranscription factors (TFs) binding to specific DNA binding sites. ETS proteinsare a... →

Research subject: The role of caspase-9 in hairfollicle stem cells. Summary: Programed cell death(PCD) serves many important functions in mammalian development and tissuehomeostasis. These include shaping tissue morphology during organogenesis... →

  One of the master transcriptional regulation hubs of every human cell is the transcription factor (TF) p53 protein. p53 is activated in response to cellular stress, and is involved... →

  The mechanistic origin of p53 selectivity and functionalityOne of the master transcriptional regulation hubs of every human cell is the transcription factor (TF) p53 protein. p53 is activated in... →

 “CRISPRscreen to identify lncRNA genes critical for SARS-CoV-2 infection” Coronavirus disease(COVID-19) is caused by the infection of Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2). The viral entry into host cells is mediated... →

 Throughoutthe last number of years, the non-protein-coding portion of the human genomehas gone from being considered “junk DNA” to “hot spots” in the area of lifescience. Genome-wide transcriptome studies indicate... →

Learn about great options in the industry at the interface of biologyand computer science Martin Akerman is a Technion Alumni who completed his undergraduate and  PhD at the Faculty of Biology.... →

Time: Thursday June 28th 13:00Place: hybrid- in the Faculty Auditorium/ZOOMhttps://technion.zoom.us/j/97658538324The HLA Peptidome of Lung Cancer: Towards the Developmentof Personalized ImmunotherapyLung cancer is the leading cause of cancer-related death worldwide, mainly... →

Title: Spatial transcriptomics ofmammalian tissuesAbstract: Mammaliantissues are composed of repeating anatomical units that are polarized bymorphogens or directional blood flow. As a result, cells at different tissuecoordinates sub-specialize in distinct physiological functions,... →

Title: Thinking outsidethe mouse: ex-vivo dissections of host-microbiome cross-talksKey points: ·        We developed a novel 3D gut organ culture system, as a uniquetool for studying host-microbiome interactions.·        Enteric neuro-immune-microbiome cross-talks control regulatoryand effector T-cells... →

Title: Rethinking Mammalian Embryonic Development: An Integrated View of Epigenetics and Cell CommitmentAbstract:One of the mostremarkable processes in biology is the development of a single fertilized egginto a complete multi-cellular embryo... →

Title:Activity Homeostasis in Neural Circuits: From Basic Principles to MalfunctionsAbstract:Maintaining averageactivity level within a set-point range constitutes a fundamentalproperty of central neural circuits. Accumulated evidence suggests that firingrate distributions and their means represent... →

Title: The power of ONE:Immunology in the age of single cell genomicsAbstract:The immune system is a complex, dynamic and plastic networkcomposed of various interacting cell types that are constantly sensing andresponding... →

Title: Innate immunity infungi: Is regulated cell death involved?Host: Benjamin Horwitz →

Title: From the Egg to the Kidney… and BackAbstract:Whatconnects the union of gametes at fertilization, a fundamental processthat ensures the transmission of genetic material through the generations, tothe defense against pathogens... →

Time: Tuesday May 17, 2022, 13:00 PMPlace: Hybrid – The Faculty og Biology AuditoriumZOOM: https://technion.zoom.us/j/91251316715Functional Super Molecular Structures of Self-assembled ProteinsAntimicrobial peptides are secreted by the innate immune system of... →

Title: New insights intoperoxisomes - small organelles with exciting biology and a huge impact on humanhealth.Abstract: Peroxisomes arecentral metabolic organelles whose decreased function gives rise to severe peroxisomaldiseases. It is recently becoming... →

Title: Physiological mechanisms of brain-body interactions Host: Sagi Levy →

Title: Decoding uniquitin signalsAbstract:UbiquitinE3-ligases regulate most of the cellular pathways and consequently are tightlyregulated themselves. Several allosteric mechanisms for regulation of HECTE3-ligases that were identified and characterized in our lab... →

Title: Nano drug delivery Host: Sagi Levy →

Title: The regulatory role of free ISG15Interferons(IFNs) are a group of cytokinesinduced by viral infection. IFN production leads to a series of protein conformationalrearrangements and interactions as well as production... →

Title: Howtranscription factors recognize binding sites in large genomes: the role ofintrinsically disordered regions.  Abstract:Transcription factors (TFs) regulate geneexpression by binding DNA sequences recognized by their DNA-binding domains (DBDs).DBD-recognized motifs... →

Place: hybrid- inthe Faculty Auditorium/ZOOM:https://technion.zoom.us/j/93473479861The role of pregnancy in skin regenerationAbstract: The physiology of mammalian skin changesdramatically during pregnancy due to immunological, metabolic, and hormonalshifts. Estrogens are major regulators of... →

Title:  Tracking the development and assembly of single cellsAbstract:  While high-throughput methods provide a sweepingbirds-eye view of development, different insights can be gained by zooming into study how a single cell... →

Title: Cis-acting gene regulationby long noncoding RNAs.  Abstract:It is now clear that many intergenic regions in eukaryoticgenomes give rise to a range of processed and regulated transcripts that do notappear... →

The ‘Hunger Games’- Structural Studies of the MC4 Receptor Reveal Mechanism for SatietyHost: Sagi LevyAbstract: Obesity is aglobal epidemic causing increased morbidity and impaired quality of life. Themelanocortin receptor 4 (MC4R)... →

Systematicidentification of gene-altering programmed inversions across the bacterialdomain Programmedchromosomal inversions allow bacteria to generate intra-population genotypicand functional heterogeneity, a bet-hedging strategy important in changingenvironmental challenges, such as bacteriophages and antibiotic drugs.... →

Title: Anti-tumor antibodies in ovarian cancer patients. Host: Sagi Levy →

Underlying mechanisms of re-programingreproduction following early life adversityA high burden of inflammatory diseasewas correlated with later puberty onset and earlier menopause in a study ofmigrant women, possibly suggesting an adaptive... →

Early-life experiencere-organizes neuromodulatory regulation of developmental patterns of behaviorand individuality   Early-life experiences may promote robust and long-lastingbehavioral outputs within populations, but also patterns of behavioralresponses that are variable among individuals, even... →

Decipheringthe role of alanine as a novel metabolic regulator of T cell immunity Abstract:T lymphocytes survey our body for threats. Under homeostasis, thesecells rarely proliferate. Upon encountering their cognate antigen and... →

The seminar will be given Hybrid: In the Faculty of Biology Auditorium and in ZOOM:https://technion.zoom.us/j/98596900607?pwd=UXk4eWk5dmZPOUFuMEl2Q1dCZ2puUT09Meeting ID: 985 9690 0607Passcode: 845596.Research Topic:Selection for resistance in marine cyanobacteria against generalist and specialist phages →

Title: Studying RNA Binding Proteins at Subcellular Resolution to Uncover their Roles in Health and Dysregulation in Disease Zoom: https://technion.zoom.us/j/96006672617 Abstract: Regulation of gene expression is at the basis of cell function.... →

Tcell starvation and nutrient competition at the tumor micro environment is considered a major limiting factor in cancer immunotherapy. Metabolic suppression hampers T cell activation, differentiation, and effector functions, leading... →

Title: Hair Raising Tale: Nerve – Stem Cell Interactions Zoom: https://technion.zoom.us/j/95140358269 Abstract: Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle, and the sympathetic nerve, providing a model to... →

Title: Filamentous actin drives nuclear architectural changes to maintain genome stability ZOOM:  https://technion.zoom.us/j/91878900904 Abstract: Cell proliferation requires efficient and accurate DNA replication. The complexity of replication, however, renders genome copying susceptible to endogenous... →

Title: The importance of being in the membraneZoom Link: :  https://technion.zoom.us/j/95594834686Abstract: With in cell membranes are numerous proteins and protein complexes that are responsible for the execution of a multitude of functions essential... →

Title: The diverse cellular and molecular mechanisms driving neuronal and axonal degenerationZoom: https://technion.zoom.us/j/98391777547Abstract: Aberrations in protein folding, processing and degradation are common features of neurodegenerative diseases, resulting in their accumulation. Amyotrophic lateral... →

Title: Toxoplasma gondii - a master manipulator: From effectordiscovery to novel concepts in cell death.Abstract: Toxoplasma gondii translocates effector proteins into its host cell tosubvert various host pathways. T. gondii effector TgIST blocks thetranscription... →