Seminars

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Bioconvergence integrates biology with engineering, computation, materials science, and physics, enabling the development of powerful platform technologies with applications across a wide range of domains, including healthcare, energy, manufacturing, environment,... →

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The Effect of Metabolites from Psilocybin-Producing Fungi on the Gut Microbiome This research investigates the impact of PAN_CINC mushroom extract on the gut-brain axis, specifically focusing on its role in... →

In Vitro Screening of the Neuroplastic Effect of Psychoactive Mushroom Extracts Neuroplasticity underlies learning, memory, and cognitive flexibility, and its impairment is a hallmark of neurological and psychiatric disorders. While... →

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Host availability effects on evolution of generalist and specialist cyanophages Obligate parasites such as bacteriophages are dependent on the availability of a sensitive host to persist. Natural environments pose challenges... →

Characterizing A-G Mismatch Signatures Associated with A-to-I RNA Editing and m6A in C. elegans RNA molecules can undergo chemical modifications that influence how they are processed and regulated. Using Caenorhabditis... →

RBM15B–DDX21 coordinates m6A writer assembly to regulate gene expression N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotes, with established roles in DNA damage response and cancer. m6A is... →

  Beyond Signal Strength: Combining biophysical properties with co-stimulatory signals to design optimal TCRL-based CAR-T cells   To address the limited efficacy of CAR T-cell therapy in solid tumors, we... →

“Host availability effects on evolution of generalist and specialist cyanophages” Obligate parasites such as bacteriophages are dependent on the availability of a sensitive host to persist. Natural environments pose challenges... →

Amyloids are functional assemblies whose structural plasticity governs biological activity. We identified fibril-forming antimicrobial peptides with reversible structural switching that modulates their function. Extending this concept to bacterial virulence, we... →

Computational Characterization of the Tumor Microenvironment for Optimizing Immunotherapy Response Immunotherapy has transformed cancer treatment, yet most patients do not achieve a durable benefit. A prevailing hypothesis is that differences... →

  Anti-epileptic effect of Amanita muscaria metabolites Affecting millions worldwide, epilepsy is a prevalent neurological disorder characterized by recurrent seizures, with many patients unresponsive to current medications. Our study sought... →

Studying lncRNA Sequence–Function Relationships Using Minimally Supervised Model   Long non-coding RNAs (lncRNAs) constitute a major regulatory component of the human transcriptome, yet their mechanisms of action and functional organization... →

RBM25 Acts as a dual chromatin- and RNA-binding regulator in Human Embryonic Stem Cells1     RNA-binding proteins are increasingly recognized to have chromatin-associated functions beyond their canonical post-transcriptional roles.... →

We propose a new theory of wheat domestication where climatic stress triggered transposable element (TE) bursts, generating vast phenotypic diversity. Unlike wild relatives where natural selection favored lower TE content,... →

The Hidden Energy of Membrane Heterogeneity In this work we develop a microscopic-scale model of a mixed membrane system. We use our results to add a correction term to the... →

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Dear Faculty Members, Students, and Staff, You are cordially invited to a faculty seminar featuring the Papers of the Month winners, which will take place next week on Monday, January 19... →

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LSm4 protein forms RNA degradation hubs at DNA breaks to facilitate repair Accurate repair of DNA double-strand breaks (DSBs) is essential for genomic stability, especially in transcriptionally active regions. Persistent... →

Dear Biology Students, Postdocs, and Faculty,   Next week for our Faculty Seminar Series at 1:00 p.m. on Monday, January 12th, we will have a talk by Dr. Uri Sheyn... →

Dear Biology Students, Postdocs, and Faculty,   Next week for our Faculty Seminar Series at 1:00 p.m. on Monday, January 5th, we will have a talk by Dr. Ron Hadas of... →

Evolution of Protein Folding and Assembly Pathways: Deciphering the Characteristics of Divergent Co-translational Assembly Pathways Protein-protein interactions are at the heart of all cellular processes, with the ribosome emerging as... →

Dear Biology Students, Postdocs, and Faculty,   Next week for our Faculty Seminar Series at 1:00 p.m. on Monday, December 29th, we will have a talk by Dr. Rachelly Normand of... →

You are invited to the Sixth lecture in the "Bridge to Industry" series:   Insights from Developing Novel Allogeneic Cell Therapies for Serious Neurological and Ophthalmic Diseases Speaker: Dr. Rami... →

Dear Biology Students, Postdocs, and Faculty,   Next week for our Faculty Seminar Series at 1:00 p.m. on Monday, December 22nd, we will have a talk by Dr. Jonathan Gropp of the... →

CRISPR targeting of H3K4me3 Reprograms Transcription, Immunity, and Meiotic Recombination in Plants Plants can develop a form of molecular memory through repeated exposure to specific stresses, allowing them to respond... →

Dear Biology Students, Postdocs, and Faculty,   Next week for our Faculty Seminar Series at 1:00 p.m. on Monday, December 15th, we will have a talk by Dr. Eman Khatib-Massalha... →

Enhancement of Human CD8+ T Cell Cytotoxicity by extracts from Amanita muscaria and Psilocybin-Producing Fungi13 Psychoactive fungi contain diverse metabolites with potential immunomodulatory properties. Here we investigated metabolites from two... →

Dear Biology Students, Postdocs, and Faculty,   Next week for our Faculty Seminar Series at 1:00 p.m. on Monday, December 8th, we will have a talk by Dr. Amir Sapir of... →

Dear Biology Students, Postdocs, and Faculty,   Next week for our Faculty Seminar Series at 1:00 p.m. on Monday, December 1st, we will have a talk by Dr. Ifat Sher-Rosenthal of... →

Dear Biology Students, Postdocs, and Faculty,   Next week for our Faculty Seminar Series at 1:00 p.m. on Monday, November 24th, we will have a talk by Dr. Schragi Schwartz of... →

You are invited to the fifth lecture in the "Bridge to Industry" series: Redefining the Boundaries of Antibody Capabilities Speaker: Dr. Yehezkel (Hezi) Sason, VP R&D, Biolojic Design Dr. Hezi... →

Dear Faculty,   Next week, we will have a lecture at 1:00 p.m. on Monday, November 17, with a talk by Dr. Dvir Aran of our faculty of Biology, at the Biology... →

  A controlled in vitro model of disuse atrophy reveals that skeletal muscle drives its own wasting via extracellular vesicles  We established a controlled in vitro model of muscle disuse... →

I am very happy to open this year’s Faculty Seminar Series at 1:00 p.m. on Monday, November 10, with a talk by Prof. Gil Ast of Tel Aviv University. Prof. Ast... →

“Game of Edits” - A-to-I RNA Editing: Thrones of Regulation, Gametogenesis and Embryogenesis   Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADARs, is a widespread and evolutionarily conserved modification needed to... →

  Immune Profiling in CD59 Deficiency: From Single-Patient scRNA-seq to Therapeutic Insights CD59 deficiency is a rare disorder in which cells are vulnerable to uncontrolled complement-mediated immune attacks. To investigate... →

Phage Resistance in Synechococcus sp. WH8109    Phage resistance plays a central role in shaping cyanobacterial population dynamics and their interactions with viruses in the ocean. The coexistence of resistant... →

Inside and Out: Antigen Type Shapes T-Cell Engager Performance Across Intracellular and Extracellular Targets   Bi-specific T-cell engagers (BiTEs) are engineered antibodies that redirect a patient’s own T cells to... →

Spatio-temporal microbial evolution dynamics  In natural microbial communities, antagonistic interactions among bacterial species, or between bacteria and phages, are important drivers of community evolution and ecological dynamics. These natural environments... →

Locally synthesized glycyl aminoacyl tRNA synthetase (GARS1) is important for  local translation in neurons Regulation of gene expression is essential for neuronal development and function. A prominent regulatory mechanism involves... →

Developing computational approaches for predicting nucleic acid binding proteins and their targets   Nucleic acid binding proteins, and specifically DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs), play a central role... →

The cumulative effect of cannabinoids on the immune system in IBD mouse models   Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract, and current... →

Investigating MMP12⁺ Macrophages as Potential Modulators of Islet Vulnerability in Type 1 Diabetes Type 1 diabetes is an autoimmune disease that leads to the selective destruction of insulin-producing pancreatic beta... →

  New players in mitochondrial protein import quality control13 Mitochondria import most of their proteins from the cytosol via dedicated channels in the outer membrane. This process is complex, and... →

13 The ubiquitin-proteasome system plays a crucial role in excessive muscle proteolysis during atrophy, a condition triggered by inactivity, starvation, aging, cancer, and muscular dystrophies. While ubiquitin ligases (E3s) have... →

 Title: Structure Prediction and Sequence Phylogeny of Fusion Family (FF) Proteins Indicate a Common Ancestor in Nematodes and Horizontal Gene Transfer Origin in Non-Nematodes13 The fusexin superfamily comprises proteins that... →

  A toolkit to decipher mechanistic insights of long non-coding RNAs based on guided CRISPR screens Long non-coding RNAs (lncRNAs) are a large and diverse group of non-protein-coding genes whose... →

Towards the Design of Targeted Therapeutics based on Microbial and Antimicrobial    Amyloids, long thought to be defined by their classic cross-β fibril structure, have recently revealed a surprising new... →

High-throughput mapping of transposon-driven genomic rearrangements under antibiotic stress   Transposons and insertion sequence (IS elements) facilitate bacterial adaptation to antibiotics through two main mechanisms. In regular transposition (insertion), an... →

Dear all,   On Tuesday, July 8th, we are delighted to host Prof. Ting Chen of Tsingua University for a special research seminar. Prof. Chen is a leading figure in computational... →

On Tuesday, July 8th, we are delighted to host Prof. Ting Chen of Tsingua University for a special research seminar. Prof. Chen is a leading figure in computational biology and medical... →

 Age-dependent differences in neuroblastoma microenvironment: integrative analysis of human and mouse single-cell RNA sequencing data   This research investigates the molecular basis of age-dependent outcome disparities in neuroblastoma, the most... →

Dear all,   Our next seminar will be given by Dr. Ayala Shiber from the Technion Faculty of Biology   Place and time: Biology auditorium, Monday 30/6 at 13:00.  ... →

Intermittent Fasting to Attenuate Age-Related Muscle Atrophy In Aging C57BL/6 Mice: Study of the Underlying Molecular Mechanisms   Sarcopenia, the age-related loss of muscle mass and strength, contributes to frailty,... →

    Split-ADAR System to Detect in vivo Co-translational Cooperativity in Single-Molecule Resolution   Protein biogenesis is challenging in the crowded cellular environment, where off-pathway interactions can lead to protein... →

Unveiling a new human SEF (IL-17RD) function in breast cancer prevention →

Dear all,   Our next seminar will be given by Dr. Ifat Sher from the Sheba Medical Center and Tel-Aviv University   Place and time: Biology auditorium, Monday 16/6 at 13:00.... →

Dear all,   Our next seminar will be given by Dr. Shay Stern from the Technion’s Faculty of Biology.   Place and time: Biology auditorium, Monday 9/6 at 13:00.  ... →

 Identification of false discoveries in sequencing data   Sequencing techniques are fundamental in almost all genetic research, either by sequencing the entire genome or transcriptome, by high-throughput sequencing, or by... →

Studying developmental patterns of social interactions in C. elegans and their effects on individuality Individuals within the same population dynamically change their social interactions across development. Understanding how these long-term... →

Dear all,   Our next seminar will be given by Prof. Amit Zeisel from the Technion’s Faculty of Biotechnology and Food Engineering   Place and time: Biology auditorium, Monday 26/5... →

Dear all,   Our next seminar will be given by Dr. Einat Segev from the Weizmann Institute of Science   Place and time: Biology auditorium, Monday 19/5 at 13:00.   Title:... →

C8orf33: A novel regulator of DNA double strand break repair choice Living organisms are continuously exposed to exogenous and endogenous DNA-damaging agents that form DNA lesions. One of the most... →

  Dear all,   Our next seminar will be given by Prof. Naama Barkai from the Weizmann Institute of Science   Place and time: Biology auditorium, Monday 12/5 at 13:00.... →

  Exploring How Antigen Type Shapes CAR T Cell Sensitivity and Function   CAR T cell therapy has revolutionized cancer treatment, yet challenges remain in targeting solid tumors. This research... →

Dear all,   Our next seminar will be given by Prof. Alexander Bershadsky from the Weizmann Institute of Science and The Mechanobiology Institute, National University of Singapore   Place and... →

Dear all,   Our next seminar will be given by Prof. Gali Prag from the School of Neurobiology, Biochemistry & Biophysics, Tel-Aviv University.   Place and time: Biology auditorium, Monday 28/4... →

Dear all,   We will have a special faculty seminar given by Dr. Saurav Mallik from the Department of Molecular Genetics, Weizmann Institute of Science.   Place and time: Biology... →

Title:  Multi-Omics Profiling of Endocannabinoid System Remodeling in Aging Alzheimer’s Disease Mice The endocannabinoid system (ECS) plays a crucial role in regulating brain homeostasis, inflammation, and aging. In this seminar,... →

   Modulating Virulent Amyloids Via Nucleic-Acid and Small Molecules Proteins and peptides can aggregate into amyloid fibrils, while their formation, structure and function are influenced by environmental and biological factors.... →

CBR: A Novel High-Light Expressed Protein and its Potential for Carotenoid Binding Chlorella ohadii, a green desert microalga, is notable for its ability to thrive under extreme high-light intensities, a... →

T Cell Dysfunction in Aging and Disease My research focuses on T cell immunity in two contexts of dysfunction: (1) Inborn errors of immunity, focusing on CARMIL2 deficiency, where we... →

"Identification and characterization of DNA damage response lncRNA by spatial-temporal analysis” Long non-coding RNAs (lncRNAs) are emerging as key regulators of cellular function, with their spatial and temporal expression playing... →

The effect of adrenarche on the reproductive axis Adrenarche is a developmental process almost unique to humans in which the adrenal glands produce high levels of dehydroepiandrosterone (DHEA) ~2-3 years... →

Exploring Light Acclimation in Microalgae Light availability drives biochemical and molecular adaptations in aquatic algae. We studied eukaryotic algae in the red-shifted-light Hula Lake via spectral incubations and transcriptomic profiling.... →

The roles and regulation of Mkrn3 in mouse hypothalamic neurons Makorin Ring Finger Protein 3 (MKRN3) functions as a "pubertal brake," and loss-of-function mutations in MKRN3 are the most common... →

AI-Driven Research and Trait Aware Representations of Medical Diagnostics   Abstract   This seminar is devoted to two separate projects:   As AI promises to accelerate scientific discovery, it remains... →

Heme toxicity in the aged spleen impairs T-cell immunity through iron deprivation   Mechanisms of T cell aging involve cell-intrinsic alterations and interactions with other immune and stromal cells. Here,... →

Identification and characterization of novel quality control factors acting in a co-translational manner   At the critical junction of translation and protein folding, the ribosome serves as a central hub,... →

Science Communication Workshop: How to present your research effectively     Second meeting:3/2/2025, Four volunteers will give their presentation and will receive feedback from the audience (focusing on the presentation... →

Join us for a seminar exploring the metabolomic diversity of psilocybin-producing fungi and their effects on immune-related disorders. This research combines standardized extraction and analytical methods with metabolomic analysis and... →

Our next seminar will be given by Dr. Avner Wallach from the Faculty of Biology, Technion - Israel Institute of Technology Place and time: Biology auditorium, Monday 27/1 at 13:00.... →

Dear all,   Our next seminar will be given by Dr. Daria Amiad Pavlov from the Perelman School of Medicine, University of Pennsylvania.   Place and time: Biology auditorium, Monday... →

Dear all,   On January 13th the faculty seminar will be given by Prof. Oliver Hobert from the Department of Biological Sciences, Columbia University.   Place and time: Biology auditorium,... →

Dear all,   Our next seminar will be given by Prof. Oliver Hobert from the Department of Biological Sciences, Columbia University.   Place and time: Biology auditorium, Monday 13/1/2025 at 13:00.... →

  TCR-like Antibodies for B Cell Malignancies. Can They Overcome Resistance to Antibody-Based CAR T Cells? Chimeric antigen receptor (CAR) T cells directed at the CD19 surface protein are an... →