Seminars

Invited Speakers : *Ori Avinoam Weizmann Institute of Science *Nicolas Brukman Technion *Yael Iosilevskii Technion *Meital Oren-Suissa Weizmann Institute of Science *Amir Sapir University of Haifa-Oranim   Please RSVP here: https://forms.gle/65JqCTiV6Ac27p1P6... →

Bridge to Industry A lecture series fostering collaboration between academia and industry. The Faculty of Biology is proud to present a series of meetings focused on groundbreaking research and innovation... →

The unique mechanisms that enable Chlorella ohadii to thrive in light intensities that are fatal to most photosynthetic organisms Although light is required for photosynthesis, too much light is harmful... →

Dear all, Our next seminar will be given by Prof. Oded Rechavi from the Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel-Aviv University.   Place and time: Biology auditorium, Monday... →

Title: Degradation of photosynthetic antennae by viral auxiliary metabolic proteins   Abstract: Cyabophage auxiliary metabolic genes have a direct and substantial effect on oceanic photosynthesis and primary productivity Cyanophages often... →

The Faculty of Biology will host our Graduate Students who won the prize for the outstanding "Paper Of The Month" in recent months at the Faculty of Biology: Ariel Chazan-... →

Identifying metabolic alterations and vulnerabilities in therapy-induced senescent cancer cells Cellular senescence, cell cycle arrest due to stress conditions, is a defense mechanism against accumulation of mutations and tumorigenesis. Therapy-induced... →

Dear all,   This week the seminar will be given by Prof. Itay Tirosh from the Department of Molecular Cell Biology a the Weizmann Institute of Science.   Place and time: Biology auditorium, Monday 11/3... →

Role of Amino-acyl tRNA synthetases in the regulation of translation of mRNAs encoding for enzymes in amino acid biosynthesis pathways Amino-acyl tRNA synthetases are enzymes that catalyse the aminoacylation reaction,... →

    This week the seminar will be given by Prof. Moshe Elkabets from the Department of Microbiology, Immunology, and Genetics at Ben-Gurion University.   Place and time: Biology auditorium, Monday 4/3 at 13:00.... →

The highly arborized PVD neuron has male-specific function and structure in C. elegans The link between sensory neuron morphology and function remains difficult to ascertain, particularly in complex organisms. The... →

Dear all,   This week the seminar will be given by Dr. Yaara Oren from the School of Medicine at Tel Aviv University.   Place and time: Biology auditorium, Monday 26/2 at 13:00.  ... →

Impact of pseudouridylation on mitochondrial tRNA recognition by cognate synthetase Mitochondrial tRNAs (mt-tRNAs) undergo an extensive post-transcriptional modification. One such common modification is pseudouridylation, the conversion of uridine to a... →

  Characterizing a role of RBM15B in  DNA Repair   DNA double-strand breaks (DSBs) are considered among the most cytotoxic DNA lesions. Cells utilize various DSB repair pathways, including homologous... →

Characterization of a Novel Macrophage Population with a Protective Potential Against Immune Attack in T1D Type 1 Diabetes (T1D) is an autoimmune disease that is characterized by insulin deficiency caused... →

Heme: A Novel Driver of Immune Aging Age-related morbidity, including the increased rate of infectious diseases, cancer, and autoimmune disorders, is driven by the decline in immune potency. The aged... →

Combining RNA- and protein-centric approaches to discover new functions of non-coding RNAs during stem cell differentiation Non-coding RNAs are at the interplay between transcription and post transcription regulation. Long non-coding... →

  Heliorhodopsins function in Gram-positive bacteria Rhodopsins are light sensing proteins that span across all kingdoms of life. They absorb light using retinal. As a response to light, rhodopsins can... →

Elucidating the mysterious ubiquitin ligase mechanism of Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Ubiquitination is a post-translational modification that has emerged as a key regulator of most cellular processes, ranging from subcellular... →

Prediction of Response to Immune Checkpoint Blockade Treatments Using Tumour Microenvironment Cellular Landscape Immune checkpoint blockade (ICB) treatments hold great promise in the realm of cancer therapy. However, they are... →

Identification and Characterization of Functional LncRNA  Regulation of Mitochondrial Respiration Carolina Khoury, Dr. Assaf C. Bester The central dogma of molecular biology traditionally emphasizes RNA's role as a messenger, bridging... →

  Foxl2 and Nr5a1 regulation in gonadotrope cells of the anterior pituitary   The mammalian reproductive system is regulated by gonadotrope cells in the anterior pituitary gland. These cells produce... →

CBDV modulates myeloid suppressor cells in the tumor microenvironment   During solid tumor progression, the tumor microenvironment (TME) evolves into a highly immunosuppressive milieu. Key players in the immunosuppressive environment... →

Identification of molecules which control in-vitro progenitor to endocrine cell differentiation of hESCs-derived pancreatic cells Type 1 diabetes is a chronic disease, caused by the loss of insulin-producing β-cells which... →

A novel cannabinoid reduces uterine hyperplasia caused by tamoxifen in mice Uterine hyperplasia is characterized by overgrowth of cells in the lining of the uterus, causing it to become thicker... →

Developing a nutrient-based formulation to attenuate muscle wasting Muscle atrophy causes weakness and disability in aging, inactivity, and in many diseases. This loss of muscle mass and strength is primarily... →

Title: Role of Myo19, an actin-based mitochondria motor, during collective cell migration.   Abstract: Cellular migration is essential for embryonic development, wound healing, immune defense, and angiogenesis, but it also... →

  Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth The folic acid cycle mediates the transfer of one-carbon (1C) units to support nucleotide biosynthesis. While the importance of... →

MyoIC's effect on nucleolar structure and organization Myosins are predominantly recognized for their role in muscle contraction and cellular cargo transport. Interestingly, one member of class IC myosin, MyolC16 (Nuclear... →

mRNAs Co-transport with Mitochondria in Neuronal Cells: Sequence Elements and Protein Factors Neurons are polarized cells with high energetic demands, which are highly dependent on localized translation of nuclear-encoded mRNAs.... →

Histone H2B ubiquitination in transcription regulation Abstract Post-translational modifications of histones play a central role in regulating all cellular processes requiring access to DNA. Cross-talk between histone modifications, in which... →

Scavenging singlet oxygen - A key to avoid photoinhibition   Light drives most life on earth as photosynthetic organisms convert it to a chemical energy. However, too much light causes... →

Silently Shaping Structure- Exploring the role of synonymous genetic coding in shaping the local protein backbone structure In the mid-20th century Christian Anfinsen, later Nobel Prize winner, showed that RNaseA... →

The immunomodulatory treasure-trove of the gut microbiota Emerging evidence demonstrates the pivotal role of gut microbes in shaping our immune system. Studies have shown a handful of immunomodulatory activities of... →

Dear Biology Faculty Students, We are excited to invite you to an exclusive meeting with a visionary leader in the healthtech field, and our esteemed Founding Director, Yona Vaisbuch, where... →

Sedimentary Ancient DNA as a tool to study Human Evolution   Viviane Slon1,2   Department of Anatomy and Anthropology and Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of... →

Imaging DNA damage and neuronal maintenance in live sleeping animals Abstract Sleep is vital for survival of all animals, ranging from jellyfish to fish and humans. Sleep improves brain performance,... →

No commitments: Planarian stem cells in regeneration and homeostasis Abstract Regeneration, the regrowth of missing organs, is a widespread survival strategy contributing to recovery from injury and disease. My lab... →

Prof. Jackie Schiller from the Faculty of Medicine in the Technion as part of the André Cohen Deloro Research Prize Ceremony. The Schiller lab studies cortical computation. →

Virulent and Antimicrobial Amyloids in Infections and Neurodegeneration   Meytal Landau   Amyloids are protein fibers with robust structures, which are known mainly in the context of neurodegenerative diseases yet... →

Structural snapshots of the cytosolic and mitochondrial mRNA translation machineries in kinetoplastids mRNA translation is a universally conserved process consisting on translating the genetic code into proteins. Translation is mainly... →

Immunoception: brain representation and control of peripheral immunity    Thoughts and emotions can impact physiology. This connection is evident in the emergence of disease following stress, psychosomatic disorders, or recovery... →

The Dance of the Amyloids: The Intricate Interactions of Pseudomonas aeruginosa Biofilm-Associated Amyloids FapB and FapC In my study, I delved into the intricate interactions of FapB and FapC, the... →

Eco-physiological research and wetland conservation: insights from pelican and cormorant studies in Israel.   The deterioration of wetlands resulting from global climate change, development, and habitat fractionation render long-distance migrating... →

Studying RNA transcription regulation via RNA-binding proteins   DRBP are proteins capable of binding DNA and RNA. Due to their dual capacity, those proteins can act at different steps of... →

Transcription Factors-RNA interaction: a new layer of cellular regulation Gene expression is a complex process tightly regulated by various proteins, including DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs). However, little... →

The ins and outs of meristem function and shape   Abstract:   Growth extent and direction determine cell and whole-organ architecture. How they are spatio-temporally coordinated across distinct cell types... →

A dual role of RBM42 in modulating splicing and translation during DNA damage response: A spotlight on CDKN1A/p21 gene   Abstract p53-mediated cell cycle arrest during DNA damage is dependent... →

Precise patterning in the inner ear   Abstract:   Precise periodic organization of cells is required for the function of many organs and tissues. It is often unclear, however, how... →

Estrogen Receptor Modulation by a Newly-Identified Phytocannabinoid in a Preclinical Model of Breast Cancer Breast cancer is made up of different subtypes that respond differently to treatments. Tumors that express... →

Characterization of Peroxismoal Proteins Changes in Response to Stress   Peroxisomes are organelles with a single bilayer membrane that encloses a soluble matrix space. Their importance is highlighted by the... →

Anti-cancer compounds from East Mediterranean seaweeds This project is aimed to study the anti-cancer effect of the East Mediterranean seaweeds to point out seaweeds of interest for future investigation and... →

  ISG15 and ISGylation at the ribosome: mechanistic analysis, innate immune response, and impact on translation   The innate immune response is the first line of defense against all pathogens.... →

Developing a single molecule approach to selective ribosome profiling   mRNA-protein interactions are at the center of the translation process. Ribosome-associated factors, from modifying enzymes to molecular chaperones, play a... →

Understanding the turnover of the truncated form of mutant ubiquitin UBB+1, UBBG76Y Ubiquitin is a 76 amino acid molecule that labels proteins for degradation. Its C-terminus at 76 glycine is... →

Reference-based deep examination of single-cell RNA-seq clusters Identifying the biological state of each single cell is arguably the most challenging task in scRNA-seq data analysis. Doing so requires bridging the... →

Title: comprehensive terminomic characterization of biological systems. Seminar abstract: Protein termini carry valuable information related to protein activity, localization, interaction and stability. Learning these various properties can be detrimental to... →

  Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression   During solid tumor progression, the tumor microenvironment (TME) evolves into a highly immunosuppressive... →

An Internal Model of Sensorimotor Context in Freely Swimming Electric Fish Internal models that predict the sensory consequences of motor actions are vital for sensory, motor, and cognitive functions. However,... →

Immunomodulation of EAE with Antibodies Targeting Autoreactive T-Cell Epitopes   Multiple sclerosis (MS) is a demyelinating autoimmune disease influencing more than 2.5 million people around the world. Damage caused in... →

The UPRmt coordinates mitochondrial network expansion and peroxisome biogenesis in the model organism Caenorhabditis elegans As organisms develop, individual cells generate mitochondria and peroxisomes to fulfill their physiological requirements. A... →

Oligodendrocyte plasticity in cognitive aging and neurodegeneration Abstract Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain aging.... →

Posters that were chosen as excellent in the departmental research days, will be presented by the graduate students. A panel of judges will choose the winning posters. A “Crowd Favorite”... →

Understanding the ancient evolution and function of innate immunity The human innate immune system has long been considered the result of extensive evolutionary innovations in metazoans. However, this dogma has... →

Study of Antigen Presentation and Antigen-Specific Immunomodulation in Multiple Sclerosis by T cell Receptor-mimic Antibodies During autoimmune diseases, like Multiple Sclerosis (MS), the immune system is downregulated in a non-specific... →

How One Eukaryotic Cell Invades Another: Dissecting Invasion by Apicomplexa The phylum Apicomplexa includes several of the most prevalent and important human eukaryotic pathogens, such as Plasmodium spp., which causes... →

Estrous cycle and Egg release resets inspired by neurodynamics in the circadian pacemaker   Jet lag and shift work disrupt the menstrual cycle and decrease fertility. The circadian pacemaker, the... →

The third lecture in the "Science Talk on the Bar" series of the Faculty of Biology About: • Is cannabis the antibiotics of the 21st century? • How many patients... →

Archaeal origins of gamete fusion Sexual reproduction consists of genome reduction by meiosis and subsequent gamete fusion. Fusexins, are a superfamily of structurally conserved proteins (fusogens) that mediate three types... →

Abstract: The fact that some amino acid chains fold alone into natively structured and fully functional proteins in solution, has led to the commonly accepted “one sequence-one structure” notion. However,... →

Arie Admon@70 symposia – Celebrating Arie's 35 years of Science "My Life with Mass Spectrometers, Proteomics, and Immunopeptidomics” Thursday, December 22, 2022; 10:00-15:00 Faculty of Biology Auditorium, Technion-Israel Institute of... →

Abstract: What are "Light Sensing" proteins and how were they discovered in the waters of the Sea of Galilee, for the first time since 1971? What is "harvesting solar energy",... →

Tales from the crypt: on helminth regulation of the stem cell compartment Abstract: Intestinal helminths remain pervasive throughout the animal kingdom by manipulating host defense pathways to prioritize tissue adaptation... →

Abstract All cells have evolved the means to store energy and thereby minimize the effects of fluctuations in nutrient availability. Cells store energy in the form of neutral lipids, such... →

During December, the faculty will hold a series of "Science TALKS over the counter" led by faculty PI in selected locations throughout Haifa and the north district. We are thrilled... →

  Reducing scRNA-seq data via nonnegative matrix factorization for annotation and clustering analysis abstract: Single-cell RNA sequencing (scRNA-seq) provides an unprecedented opportunity to dissect tissue heterogeneity and characterize individual cells.... →

Abstract Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain aging. Cerebrospinal fluid (CSF) makes up the immediate... →

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  https://en.globes.co.il/en/article-genome-sequencing-co-ultima-genomics-raises-600m-1001414037   Genome sequencing company Ultima Genomics has come out of stealth and announced $600 million in financing. Founded in 2016 by its Israeli CEO Gilad Almogy, the company... →

Tales of protein tails and the proteases that generate them Proteolysis is one of the mechanisms that allows cells to alter their proteome in response to different conditions or signals.... →

  Thermodynamic models for the homeostasis and development of the epidermis and spherical organoids Epithelial tissues formed of layered cell surfaces are prevalent in multiple tissues and play an essential... →

Abstract: Cellular plasticity is emerging as an important driving force underlying cancer progression and drug resistance. In this talk, I will discuss the concept of cancer cell states present in... →

Abstract:   The formal scientific method tells you how to rigorously and objectively test a hypothesis. But where do hypotheses come from in the first place? Posing fruitful new questions,... →

The Ayoub lab studies DNA damage repair, genome stability and cancer. Ayoub lab: http://ayoubn.net.technion.ac.il/ →

Graph Theory Approaches for Network Analysis of Neuronal Signals and Behavior How does the brain encode behavior? What are the internal mechanisms affecting neuronal network organization and configuration at different... →

Adult stem cells (SCs) are tissue-specific resident cells that serve to replenish and maintain the tissue. Two significant SC populations co-exist in the hair follicle: hair follicle SCs (HFSCs) and... →

Exocytosis by membrane crumpling maintains homeostasis during exocrine secretion Dynamic membrane remodeling is essential for life. Cells, organelles, and vesicles must constantly acquire, maintain and modify their shape and composition... →

10:00-10:30 - Gathering, coffee, and cakes 10:30-10:40 - Opening Remarks, Faculty Dean Yael Mandel Gutfreund 10:40-10:50 – Introduction, Yoram Reiter 10:50-11:20 - Michael Boshart, Genetics - Biocenter LMU, München Protein... →

"The Antitumor Effects of Cannabinoids in Glioblastoma Multiforme" Glioblastoma multiforme is an aggressive brain tumor whose current treatments are insufficient due to its high invasiveness and heterogeneity, rapid growth and... →

What mechanism protects the heart from fasting-induced atrophy? Skeletal muscles atrophy upon systemic fasting, when blood glucose and insulin levels are low. However, the heart is relatively protected, and atrophy... →

Revealing Hormone-Mediated Tissue-Specific Nuclear Proteome and Signaling Output in the Meristem Our lab seeks to understand the principles underlying developmental programs in plants. Using roots as a model organ, we... →

The Effect of Cannabinoids on Microglial Phagocytosis of Amyloid-beta: Implications for Alzheimer’s Disease During the progression of the neurodegenerative Alzheimer’s disease, amyloid-β peptides accumulate in the brain to form toxic... →

Title: Linking learning to behaviour via neural representation geometry. Abstract: Recent developments in experimental neuroscience enable us to simultaneously record the activity of a large number of neurons and to... →

Programmed Cell Death RegulatesSebaceous Gland Homeostasis and Pathology   In the past decade, most studies investigating mammalian skin havefocused on the epidermis and the hair follicle, whereas much less is... →

Apoptoticcells represent a dynamic stem cell niche governing proliferation and tissueregeneration   Summery Stem cells (SCs) play a key role inhomeostasis and repair. While many studies have focused on SC... →

Roles of Aminoacyl tRNA synthetases in mRNA regulation Aminoacyl tRNA synthetases (aaRSs) are a well-studied family of enzymes with a canonical role in charging tRNA with specific amino acid. Yet,... →

Studying the functionalsignificance of RNA editing and duplicated genomic regions in Caenorhabditiselegans RNAediting is a phenomenon of RNA sequence alteration after transcription ineukaryotes. In mammals, the most common alterations studied... →

Shape readout by the transcription factor ETS1 of its RE's   Transcription in eukaryotes is under the control oftranscription factors (TFs) binding to specific DNA binding sites. ETS proteinsare a... →

Research subject: The role of caspase-9 in hairfollicle stem cells. Summary: Programed cell death(PCD) serves many important functions in mammalian development and tissuehomeostasis. These include shaping tissue morphology during organogenesis... →

  One of the master transcriptional regulation hubs of every human cell is the transcription factor (TF) p53 protein. p53 is activated in response to cellular stress, and is involved... →